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Cellosaurus HuH7-2C8D (CVCL_C8HR)

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Cell line name HuH7-2C8D
Accession CVCL_C8HR
Resource Identification Initiative To cite this cell line use: HuH7-2C8D (RRID:CVCL_C8HR)
Comments Population: Japanese.
Virology: Produces hepatitis D virus (HDV) infectious particles (PubMed=36511319).
Virology: Transfected with pSVLD3-neo, a plasmid harboring 3 copies of the HDV genome (PubMed=36511319).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03138; Hepatitis B virus genotype D subtype ayw envelope protein (HBsAg).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C8HQ (HuH7-2C8)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
Publications

PubMed=36511319; DOI=10.1016/j.antiviral.2022.105477
Charlotte Bach, Julie Lucifora, Marion Delphin, Laura Heydmann, Margaux J. Heuschkel, Caroline Pons, Kaku Goto, Els Scheers, Catherine Schuster, David Durantel, Frederik Pauwels ...Show all 13 authors... , Thomas F. Baumert, Eloi R. Verrier; Show fewer authors
A stable hepatitis D virus-producing cell line for host target and drug discovery.
Antiviral Res. 209:105477.1-105477.12(2023)

Cross-references
Encyclopedic resources Wikidata; Q123032650
Entry history
Entry creation05-Oct-2023
Last entry update14-Aug-2025
Version number6