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Cellosaurus RAW 264.7 Lrrk2 KO (CVCL_C8HC)

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Cell line name RAW 264.7 Lrrk2 KO
Synonyms LRRK2 KO RAW 264.7; LRRK2KO; LRRK2 KO; LKO
Accession CVCL_C8HC
Resource Identification Initiative To cite this cell line use: RAW 264.7 Lrrk2 KO (RRID:CVCL_C8HC)
Comments Knockout cell: Method=CRISPR/Cas9; MGI; MGI:1913975; Lrrk2.
Transformant: NCBI_TaxID; 11788; Abelson mouse leukemia virus (AbMuLV).
Miscellaneous: Cell line information from personal communication of Rodriguez-Moya, Lilia.
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Cell type: Macrophage; CL=CL_0000235.
Disease Mouse leukemia (NCIt: C21604)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/c.
Hierarchy Parent: CVCL_0493 (RAW 264.7)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
Publications

DOI=10.1101/2025.08.25.672135
Andres Goldman, Mai Nguyen, Joel Lanoix, Ahmed Fahmy, Yong Zhong Xu, Erwin Schurr, Pierre Thibault, Michel Desjardins, Heidi M. McBride;
LRRK2G2019S acts as a dominant interfering mutant in the context of iron overload.
bioRxiv 2025:08.25.672135-08.25.672135(2025)

Cross-references
Encyclopedic resources Wikidata; Q123033318
Entry history
Entry creation05-Oct-2023
Last entry update25-Jun-2026
Version number5