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Cellosaurus TK 188 (CVCL_C8FB)

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Cell line name TK 188
Synonyms Tk 188; tFKIF; transformed Fibroblasts from Kidney with Interstitial Fibrosis
Accession CVCL_C8FB
Resource Identification Initiative To cite this cell line use: TK 188 (RRID:CVCL_C8FB)
Comments Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P0A9M5; Escherichia coli gpt.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pSV3-gpt).
Donor information: Established from a patient suffering from tubulointerstitial fibrosis.
Derived from site: In situ; Kidney; Note=Fibrotic; UBERON=UBERON_0002113.
Cell type: Renal interstitial fibroblast; CL=CL_1000692.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=7773632
Gerhard Anton Muller, John Frank, Hans Peter Rodemann, Gabi Engler-Blum;
Human renal fibroblast cell lines (tFKIF and tNKF) are new tools to investigate pathophysiologic mechanisms of renal interstitial fibrosis.
Exp. Nephrol. 3:127-133(1995)

PubMed=12684791; DOI=10.1007/s00424-003-1026-y
Jan Bernd Schuttert, M.H. Liu, Nina Gliem, Georg Martin Fiedler, Steffen Zopf, Christof Mayer, Gerhard Anton Muller, Rolf Willi Grunewald;
Human renal fibroblasts derived from normal and fibrotic kidneys show differences in increase of extracellular matrix synthesis and cell proliferation upon angiotensin II exposure.
Pflugers Arch. 446:387-393(2003)

Cross-references
Encyclopedic resources Wikidata; Q123033619
Entry history
Entry creation29-Jun-2023
Last entry update14-Aug-2025
Version number6