ID   TK 188
AC   CVCL_C8FB
SY   Tk 188; tFKIF; transformed Fibroblasts from Kidney with Interstitial Fibrosis
DR   Wikidata; Q123033619
RX   PubMed=7773632;
RX   PubMed=12684791;
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P0A9M5; Escherichia coli gpt.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pSV3-gpt).
CC   Donor information: Established from a patient suffering from tubulointerstitial fibrosis.
CC   Derived from site: In situ; Kidney; Note=Fibrotic; UBERON=UBERON_0002113.
CC   Cell type: Renal interstitial fibroblast; CL=CL_1000692.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Adult
CA   Transformed cell line
DT   Created: 29-06-23; Last updated: 14-08-25; Version: 6
//
RX   PubMed=7773632;
RA   Muller, Gerhard Anton
RA   Frank, John
RA   Rodemann, Hans Peter
RA   Engler-Blum, Gabi
RT   "Human renal fibroblast cell lines (tFKIF and tNKF) are new tools to
RT   investigate pathophysiologic mechanisms of renal interstitial
RT   fibrosis.";
RL   Exp. Nephrol. 3:127-133(1995).
//
RX   PubMed=12684791; DOI=10.1007/s00424-003-1026-y;
RA   Schuttert, Jan Bernd
RA   Liu, M.H.
RA   Gliem, Nina
RA   Fiedler, Georg Martin
RA   Zopf, Steffen
RA   Mayer, Christof
RA   Muller, Gerhard Anton
RA   Grunewald, Rolf Willi
RT   "Human renal fibroblasts derived from normal and fibrotic kidneys show
RT   differences in increase of extracellular matrix synthesis and cell
RT   proliferation upon angiotensin II exposure.";
RL   Pflugers Arch. 446:387-393(2003).
//