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Cellosaurus HC50474 (CVCL_C8C7)

[Text version]
Cell line name HC50474
Synonyms HC474
Accession CVCL_C8C7
Resource Identification Initiative To cite this cell line use: HC50474 (RRID:CVCL_C8C7)
Comments Characteristics: Overproduces adenylate deaminase (PubMed=6526013).
Selected for resistance to: ChEBI; CHEBI_16213; Coformycin.
Selected for resistance to: ChEBI; CHEBI_28680; Cytarabine (Arabinosylcytosine; Ara-C).
Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_C8C4 (HC1047)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=6526013; DOI=10.1002/j.1460-2075.1984.tb02268.x; PMCID=PMC557827
Debatisse M., Robert de Saint-Vincent B., Buttin G.
Expression of several amplified genes in an adenylate-deaminase overproducing variant of Chinese hamster fibroblasts.
EMBO J. 3:3123-3127(1984)

PubMed=3785179; DOI=10.1128/mcb.6.5.1776-1781.1986; PMCID=PMC367706
Debatisse M., Hyrien O., Petit-Koskas E., Robert de Saint-Vincent B., Buttin G.
Segregation and rearrangement of coamplified genes in different lineages of mutant cells that overproduce adenylate deaminase.
Mol. Cell. Biol. 6:1776-1781(1986)

PubMed=8569793; DOI=10.1016/0027-5107(95)00153-0
Lunel-Orsini C., Buttin G., Robert de Saint-Vincent B.
Reversion in Chinese hamster lines amplified at the AMPD2 locus: spontaneous and benzamide-stimulated gradual loss of amplified alleles of marker genes.
Mutat. Res. 349:63-75(1996)

Cross-references
Encyclopedic resources Wikidata; Q123031529
Entry history
Entry creation29-Jun-2023
Last entry update19-Dec-2024
Version number3