Cellosaurus Pre-i3Neuron NGN2 iPSC LRRK2-p.G2019S knock-in (CVCL_C7XK)
| Cell line name | Pre-i3Neuron NGN2 iPSC LRRK2-p.G2019S knock-in |
|---|---|
| Accession | CVCL_C7XK |
| Resource Identification Initiative | To cite this cell line use: Pre-i3Neuron NGN2 iPSC LRRK2-p.G2019S knock-in (RRID:CVCL_C7XK) |
| Comments | Population: Japanese. Characteristics: Using TALEN a PuroR-CAG-rtTA3G-NEUROG2 construct was introduced in both alleles of the AAVS1 safe harbor locus thus providing doxycycline-inducible expression of NEUROG2/NGN2 (from parent cell line). Transfected with: HGNC; 13805; NEUROG2. Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR). Miscellaneous: Cell line information from personal communication of Dou D. Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511. Cell type: Fibroblast of skin; CL=CL_0002620. |
| Sequence variations |
|
| Disease | Parkinson disease 8, autosomal dominant (NCIt: C198605) Hereditary late-onset Parkinson disease (ORDO: Orphanet_411602) |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_C7XJ (Pre-i3Neuron NGN2 iPSC clone 1) |
| Sex of cell | Male |
| Age at sampling | 30Y |
| Category | Induced pluripotent stem cell |
| Cross-references | |
| Encyclopedic resources | Wikidata; Q123033275 |
| Entry history | |
| Entry creation | 29-Jun-2023 |
| Last entry update | 30-Jan-2024 |
| Version number | 2 |