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Cellosaurus Pre-i3Neuron NGN2 iPSC clone 1 (CVCL_C7XJ)

[Text version]
Cell line name Pre-i3Neuron NGN2 iPSC clone 1
Synonyms i3N iPSC clone 1
Accession CVCL_C7XJ
Resource Identification Initiative To cite this cell line use: Pre-i3Neuron NGN2 iPSC clone 1 (RRID:CVCL_C7XJ)
Comments Population: Japanese.
Characteristics: Using TALEN a PuroR-CAG-rtTA3G-NEUROG2 construct was introduced in both alleles of the AAVS1 safe harbor locus thus providing doxycycline-inducible expression of NEUROG2/NGN2 (PubMed=28966121).
Transfected with: HGNC; 13805; NEUROG2.
Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Cell type: Fibroblast of skin; CL=CL_0002620.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_Y803 (GM25256)
Children:
CVCL_C7XK (Pre-i3Neuron NGN2 iPSC LRRK2-p.G2019S knock-in)
Sex of cell Male
Age at sampling 30Y
Category Induced pluripotent stem cell
Publications

PubMed=28966121; DOI=10.1016/j.stemcr.2017.08.019
Wang C., Ward M.E., Chen R., Liu K., Tracy T.E., Chen X., Xie M., Sohn P.D., Ludwig C., Meyer-Franke A., Karch C.M., Ding S., Gan L.
Scalable production of iPSC-derived human neurons to identify Tau-lowering compounds by high-content screening.
Stem Cell Reports 9:1221-1233(2017)

Cross-references
Encyclopedic resources Wikidata; Q123033274
Entry history
Entry creation29-Jun-2023
Last entry update30-Jan-2024
Version number2