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Cellosaurus WIRL-3C (CVCL_C7X4)

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Cell line name WIRL-3C
Synonyms WIstar Rat Liver-3C
Accession CVCL_C7X4
Resource Identification Initiative To cite this cell line use: WIRL-3C (RRID:CVCL_C7X4)
Comments Senescence: After passage 55, the cells either die or form a continuous cell line which morphologically is more transformed and proliferates rapidly (PubMed=206565).
Doubling time: 19-22 hours (PubMed=4147851); 12 hours (PubMed=7440648).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Wistar; RS=RS_0000955.
Originate from same individual CVCL_C7X3 ! WIRL-3B
Sex of cell Male
Age at sampling 4W
Category Spontaneously immortalized cell line
Publications

PubMed=4147851
Leila Diamond, Rosemary C. McFall, Yutaka Tashiro, David Marcelo Sabatini;
The WIRL-3 rat liver cell lines and their transformed derivatives.
Cancer Res. 33:2627-2636(1973)

PubMed=206565; DOI=10.1002/jcp.1040950203
Harriet C. Isom, Lewis I. Pizer;
Growth dependence of phosphoglyceric acid dehydrogenase activity in cultured rat liver cells.
J. Cell. Physiol. 95:139-150(1978)

PubMed=6939365; DOI=10.1111/j.1749-6632.1980.tb29538.x
Nebojsa Avdalovic;
Bromodeoxyuridine-induced changes in the transformed phenotype.
Ann. N. Y. Acad. Sci. 349:346-356(1980)

PubMed=7440648; DOI=10.1002/jcp.1041040112
Nebojsa Avdalovic, Joseph Weibel, Leila Diamond;
The effects of 5-bromodeoxyuridine on the growth and morphology of transformed rat liver cells.
J. Cell. Physiol. 104:83-96(1980)

PubMed=3431441; DOI=10.1016/s0076-6879(87)51006-0
Gretchen J. Darlington;
Liver cell lines.
Methods Enzymol. 151:19-38(1987)

Cross-references
Encyclopedic resources Wikidata; Q123033922
Entry history
Entry creation29-Jun-2023
Last entry update10-Apr-2025
Version number5