ID   WIRL-3C
AC   CVCL_C7X4
SY   WIstar Rat Liver-3C
DR   Wikidata; Q123033922
RX   PubMed=206565;
RX   PubMed=3431441;
RX   PubMed=4147851;
RX   PubMed=6939365;
RX   PubMed=7440648;
CC   Senescence: After passage 55, the cells either die or form a continuous cell line which morphologically is more transformed and proliferates rapidly (PubMed=206565).
CC   Doubling time: 19-22 hours (PubMed=4147851); 12 hours (PubMed=7440648).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
CC   Cell type: Epithelial cell; CL=CL_0000066.
CC   Breed/subspecies: Wistar; RS=RS_0000955.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
OI   CVCL_C7X3 ! WIRL-3B
SX   Male
AG   4W
CA   Spontaneously immortalized cell line
DT   Created: 29-06-23; Last updated: 10-04-25; Version: 5
//
RX   PubMed=6939365; DOI=10.1111/j.1749-6632.1980.tb29538.x;
RA   Avdalovic, Nebojsa
RT   "Bromodeoxyuridine-induced changes in the transformed phenotype.";
RL   Ann. N. Y. Acad. Sci. 349:346-356(1980).
//
RX   PubMed=7440648; DOI=10.1002/jcp.1041040112;
RA   Avdalovic, Nebojsa
RA   Weibel, Joseph
RA   Diamond, Leila
RT   "The effects of 5-bromodeoxyuridine on the growth and morphology of
RT   transformed rat liver cells.";
RL   J. Cell. Physiol. 104:83-96(1980).
//
RX   PubMed=4147851;
RA   Diamond, Leila
RA   McFall, Rosemary C.
RA   Tashiro, Yutaka
RA   Sabatini, David Marcelo
RT   "The WIRL-3 rat liver cell lines and their transformed derivatives.";
RL   Cancer Res. 33:2627-2636(1973).
//
RX   PubMed=206565; DOI=10.1002/jcp.1040950203;
RA   Isom, Harriet C.
RA   Pizer, Lewis I.
RT   "Growth dependence of phosphoglyceric acid dehydrogenase activity in
RT   cultured rat liver cells.";
RL   J. Cell. Physiol. 95:139-150(1978).
//
RX   PubMed=3431441; DOI=10.1016/s0076-6879(87)51006-0;
RA   Darlington, Gretchen J.
RT   "Liver cell lines.";
RL   Methods Enzymol. 151:19-38(1987).
//