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Cellosaurus Vero PVR1/2 DKO hSLAM+ (CVCL_C7UT)

[Text version]
Cell line name Vero PVR1/2 DKO hSLAM+
Synonyms Vero deltaPVR1/2 hSLAM+ c1
Accession CVCL_C7UT
Resource Identification Initiative To cite this cell line use: Vero PVR1/2 DKO hSLAM+ (RRID:CVCL_C7UT)
Comments Group: Non-human primate cell line.
Virology: Not susceptible to infection by poliovirus. Useful for the isolation of measles virus (MeV) and rubella virus (RuV) as both viruses replicate efficiently in this cell line (PubMed=36564197).
Knockout cell: Method=CRISPR/Cas9; UniProtKB; A0A0D9S1N4; PVR1.
Knockout cell: Method=CRISPR/Cas9; UniProtKB; A0A0D9S1L1; PVR2.
Transfected with: HGNC; 10903; SLAMF1.
Transfected with: UniProtKB; P33967; B.cereus Bsr.
Derived from site: In situ; Kidney, epithelium; UBERON=UBERON_0004819.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) (NCBI Taxonomy: 60711)
Hierarchy Parent: CVCL_B3LS (Vero PVR1/2 DKO)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=36564197; DOI=10.1111/1348-0421.13047
Someya K., Okemoto-Nakamura Y., Kurata T., Kanbayashi D., Saito N., Itamochi M., Otsuki N., Hanada K., Takeda M.
Establishment of measles virus receptor-expressing Vero cells lacking functional poliovirus receptors.
Microbiol. Immunol. 67:166-170(2023)

Cross-references
Cell line collections (Providers) JCRB; JCRB1901
Encyclopedic resources Wikidata; Q123033771
Entry history
Entry creation29-Jun-2023
Last entry update30-Jan-2024
Version number3