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Cellosaurus LD-1 (CVCL_C7SL)

[Text version]
Cell line name LD-1
Synonyms LD1
Accession CVCL_C7SL
Resource Identification Initiative To cite this cell line use: LD-1 (RRID:CVCL_C7SL)
Comments Genetic integration: Method=Transfection; Gene=MGI; MGI:87986; Akt1.
Genetic integration: Method=Transfection; Gene=MGI; MGI:103262; Yap1.
Transformant: Akt1 and Yap1.
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Mouse cholangiocarcinoma (NCIt: C38739)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Category Cancer cell line
Publications

PubMed=33323397; DOI=10.1158/2159-8290.CD-20-0304; PMCID=PMC8102309
Qian-Fei Zhang, Chi Ma, Yi Duan, Bernd Heinrich, Umberto Rosato, Laurence P. Diggs, Li-Chun Ma, Soumen Roy, Qiong Fu, Zachary J. Brown, Simon Wabitsch ...Show all 31 authors... , Vishal Thovarai, Jian-Yang Fu, De-Chun Feng, Benjamin Ruf, Linda L. Cui, Varun Subramanyam, Karen M. Frank, Sophie Wang, David E. Kleiner, Thomas Ritz, Christian Rupp, Bin Gao, Thomas Longerich, Alexander Helmut Kurt Kroemer, Xin-Wei Wang, Mathuros Ruchirawat, Firouzeh Korangy, Bernd Schnabl, Giorgio Trinchieri, Tim F. Greten; Show fewer authors
Gut microbiome directs hepatocytes to recruit MDSCs and promote cholangiocarcinoma.
Cancer Discov. 11:1248-1267(2021)

PubMed=34033968; DOI=10.1016/j.jcmgh.2021.05.011; PMCID=PMC8413239
Simon Wabitsch, Mayank Tandon, Benjamin Ruf, Qian-Fei Zhang, Justin D. McCallen, John C. McVey, Chi Ma, Benjamin L. Green, Laurence P. Diggs, Bernd Heinrich, Tim F. Greten;
Anti-PD-1 in combination with trametinib suppresses tumor growth and improves survival of intrahepatic cholangiocarcinoma in mice.
Cell. Mol. Gastroenterol. Hepatol. 12:1166-1178(2021)

Cross-references
Cell line collections (Providers) Kerafast; ECD039-FP
Encyclopedic resources Wikidata; Q117704632
Entry history
Entry creation21-Mar-2023
Last entry update10-Apr-2025
Version number4