ID   LD-1
AC   CVCL_C7SL
SY   LD1
DR   Kerafast; ECD039-FP
DR   Wikidata; Q117704632
RX   PubMed=33323397;
RX   PubMed=34033968;
CC   Genetic integration: Method=Transfection; Gene=MGI; MGI:87986; Akt1.
CC   Genetic integration: Method=Transfection; Gene=MGI; MGI:103262; Yap1.
CC   Transformant: Akt1 and Yap1.
CC   Omics: Genomics; Whole exome sequencing.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
CC   Breed/subspecies: C57BL/6.
DI   NCIt; C38739; Mouse cholangiocarcinoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
CA   Cancer cell line
DT   Created: 21-03-23; Last updated: 10-04-25; Version: 4
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RX   PubMed=33323397; DOI=10.1158/2159-8290.CD-20-0304; PMCID=PMC8102309;
RA   Zhang Q.-F., Ma C., Duan Y., Heinrich B., Rosato U., Diggs L.P.,
RA   Ma L.-C., Roy S., Fu Q., Brown Z.J., Wabitsch S., Thovarai V.,
RA   Fu J.-Y., Feng D.-C., Ruf B., Cui L.L., Subramanyam V., Frank K.M.,
RA   Wang S., Kleiner D.E., Ritz T., Rupp C., Gao B., Longerich T.,
RA   Kroemer A.H.K., Wang X.-W., Ruchirawat M., Korangy F., Schnabl B.,
RA   Trinchieri G., Greten T.F.;
RT   "Gut microbiome directs hepatocytes to recruit MDSCs and promote
RT   cholangiocarcinoma.";
RL   Cancer Discov. 11:1248-1267(2021).
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RX   PubMed=34033968; DOI=10.1016/j.jcmgh.2021.05.011; PMCID=PMC8413239;
RA   Wabitsch S., Tandon M., Ruf B., Zhang Q.-F., McCallen J.D., McVey J.C.,
RA   Ma C., Green B.L., Diggs L.P., Heinrich B., Greten T.F.;
RT   "Anti-PD-1 in combination with trametinib suppresses tumor growth and
RT   improves survival of intrahepatic cholangiocarcinoma in mice.";
RL   Cell. Mol. Gastroenterol. Hepatol. 12:1166-1178(2021).
//