Cellosaurus cell line MCF10A-EGFR1m-1 (CVCL

Cellosaurus MCF10A-EGFR1m-1 (CVCL_C7Q2)

Cross-references
Cell line name	MCF10A-EGFR1m-1
Synonyms	MCF10A-EGFR-1_type-01; 06M01002
Accession	CVCL_C7Q2
Resource Identification Initiative	To cite this cell line use: MCF10A-EGFR1m-1 (RRID:CVCL_C7Q2)
Comments	Part of: Fukushima Translational Research Project gene-overexpressing cell lines panel. Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3236; EGFR (Note=With p.Leu858Arg (c.2573T>G)). Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0598 (MCF-10A)
Sex of cell	Female
Age at sampling	36Y
Category	Spontaneously immortalized cell line
Web pages	Info; FTRP; -; https://www.fmu.ac.jp/home/trc/en/contract-research-provision/human-gene-overexpressing-cell-lines/
Publications	PubMed=27840973; DOI=10.3892/or.2016.5227; PMCID=PMC5355725 Hirotaka Hoshi, Gen Hiyama, Kosuke Ishikawa, Kiyoshi Inageda, Jiro Fujimoto, Ai Wakamatsu, Takushi Togashi, Yoshifumi Kawamura, Nobuhiko Takahashi, Arisa Higa, Naoki Goshima ...Show all 14 authors... , Kentaro Semba, Shinya Watanabe, Motoki Takagi; Show fewer authors Construction of a novel cell-based assay for the evaluation of anti-EGFR drug efficacy against EGFR mutation. Oncol. Rep. 37:66-76(2017)
Cell line collections (Providers)	CancerTools; 161168
Encyclopedic resources	Wikidata; Q117704643
Entry history
Entry creation	21-Mar-2023
Last entry update	10-Apr-2025
Version number	5