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Cellosaurus K562-mb15-41BBL (CVCL_C7IM)

[Text version]
Cell line name K562-mb15-41BBL
Accession CVCL_C7IM
Resource Identification Initiative To cite this cell line use: K562-mb15-41BBL (RRID:CVCL_C7IM)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5977; IL15 (Note=Membrane bound, contains the signal peptide of CD8A, the mature part of IL15 and the transmembrane domain of CD8A).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11939; TNFSF9.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C7IL (K562-mb15)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=15755898; DOI=10.1182/blood-2004-12-4797; PMCID=PMC1895123
Chihaya Imai, Shotaro Iwamoto, Dario Campana;
Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells.
Blood 106:376-383(2005)

Cross-references
Encyclopedic resources Wikidata; Q117704569
Entry history
Entry creation21-Mar-2023
Last entry update10-Apr-2025
Version number6