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Cellosaurus K562-mb15 (CVCL_C7IL)

[Text version]
Cell line name K562-mb15
Accession CVCL_C7IL
Resource Identification Initiative To cite this cell line use: K562-mb15 (RRID:CVCL_C7IL)
Comments Population: Caucasian.
Transfected with: HGNC; 5977; IL15 (membrane bound, contains the signal peptide of CD8A, the mature part of IL15 and the transmembrane domain of CD8A).
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Children:
CVCL_C7IM (K562-mb15-41BBL)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=15755898; DOI=10.1182/blood-2004-12-4797
Imai C., Iwamoto S., Campana D.
Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells.
Blood 106:376-383(2005)

Cross-references
Encyclopedic resources Wikidata; Q117704568
Entry history
Entry creation21-Mar-2023
Last entry update29-Jun-2023
Version number2