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Cellosaurus 67-2 (CVCL_C7I4)

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Cell line name 67-2
Accession CVCL_C7I4
Resource Identification Initiative To cite this cell line use: 67-2 (RRID:CVCL_C7I4)
Comments Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized pepinemab (VX15/2503) therapeutic antibody which is used in clinical trials for the treatment of a number of neuroinflammatory/neurodegenerative diseases.
Monoclonal antibody isotype: IgG1.
Monoclonal antibody target: UniProtKB; Q92854; Human SEMA4D/CD100 (Note=Also reacts with mouse).
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_4032 (P3X63Ag8.653)
Category Hybridoma
Publications

PubMed=26431358; DOI=10.1080/19420862.2015.1102813; PMCID=PMC4966508
Terrence L. Fisher, Christine A. Reilly, Laurie A. Winter, Tracy Pandina, Alan Jonason, Maria Scrivens, Leslie Balch, Holm Bussler, Sebold Torno, Jennifer Seils, Loretta Mueller ...Show all 20 authors... , He Huang, Ekaterina Klimatcheva, Alan Howell, Renee Kirk, Elizabeth E. Evans, Mark Paris, John E. Leonard, Ernest S. Smith, Maurice Zauderer; Show fewer authors
Generation and preclinical characterization of an antibody specific for SEMA4D.
MAbs 8:150-162(2016)

Cross-references
Encyclopedic resources Wikidata; Q123030309
Entry history
Entry creation21-Mar-2023
Last entry update30-Jan-2024
Version number2