ID   67-2
AC   CVCL_C7I4
DR   Wikidata; Q123030309
RX   PubMed=26431358;
CC   Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized pepinemab (VX15/2503) therapeutic antibody which is used in clinical trials for the treatment of a number of neuroinflammatory/neurodegenerative diseases.
CC   Monoclonal antibody isotype: IgG1.
CC   Monoclonal antibody target: UniProtKB; Q92854; Human SEMA4D/CD100 (Note=Also reacts with mouse).
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_4032 ! P3X63Ag8.653
CA   Hybridoma
DT   Created: 21-03-23; Last updated: 30-01-24; Version: 2
//
RX   PubMed=26431358; DOI=10.1080/19420862.2015.1102813;
RA   Fisher T.L., Reilly C.A., Winter L.A., Pandina T., Jonason A.,
RA   Scrivens M., Balch L., Bussler H., Torno S., Seils J., Mueller L.,
RA   Huang H., Klimatcheva E., Howell A., Kirk R., Evans E.E., Paris M.,
RA   Leonard J.E., Smith E.S., Zauderer M.;
RT   "Generation and preclinical characterization of an antibody specific
RT   for SEMA4D.";
RL   MAbs 8:150-162(2016).
//