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Cellosaurus OVTW59-P4 (CVCL_C6VT)

[Text version]
Cell line name OVTW59-P4
Synonyms OVTW59 P4; OVTW-59-P4; OVTW-59-4
Accession CVCL_C6VT
Resource Identification Initiative To cite this cell line use: OVTW59-P4 (RRID:CVCL_C6VT)
Comments Population: Chinese; Taiwan.
Characteristics: High invasive phenotype. Selected from parent cell line for invasion phenotype using Matrigel-coated transwell membranes. P4 are P3-derived cells that had invaded through the Matrigel (PubMed=17952116).
Doubling time: 19 hours (PubMed=17952116).
Karyotypic information: XXX,t(3;12),t(5;8),t(6;15),t(11;12),t(15;22),del(7)(q22),-4,+12,+14,+14,-18,-19,+21,-22,-22 (PubMed=17952116).
Derived from site: In situ; Ovary, epithelium; UBERON=UBERON_0004911.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C6VS (OVTW59-P3)
Children:
CVCL_C6VU (OVTW59-P4-pBIG2i-hIGFBP3)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=17952116; DOI=10.1038/sj.onc.1210864
Torng P.-L., Lee Y.-C.G., Huang C.-Y.F., Ye J.-H., Lin Y.-S., Chu Y.-W., Huang S.-C., Cohen P., Wu C.-W., Lin C.-T.
Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma.
Oncogene 27:2137-2147(2008)

PubMed=34824343; DOI=10.1038/s41598-021-02400-1; PMCID=PMC8616920
Shih H.-J., Chang H.-F., Chen C.-L., Torng P.-L.
Differential expression of hypoxia-inducible factors related to the invasiveness of epithelial ovarian cancer.
Sci. Rep. 11:22925.1-22925.13(2021)

Cross-references
Encyclopedic resources Wikidata; Q117704765
Entry history
Entry creation21-Mar-2023
Last entry update29-Jun-2023
Version number2