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Cellosaurus STC-1 pGIP/Neo (CVCL_C6ND)

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Cell line name STC-1 pGIP/Neo
Synonyms pGIP/Neo STC-1; pGIP/Neo
Accession CVCL_C6ND
Resource Identification Initiative To cite this cell line use: STC-1 pGIP/Neo (RRID:CVCL_C6ND)
Comments Characteristics: Expression of the neo gene is driven by a rat GIP promoter (PubMed=12124779).
Characteristics: Compared to parent cell line secrete 3-6 times more GIP and substantially less CCK and PYY (PubMed=22768997).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P68835; Murine polyomavirus (strain A2) (MPyV) small T antigen (PyST).
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 10636; Murine polyomavirus (strain A2) (MPyV).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Small intestine, duodenum; UBERON=UBERON_0002114.
Disease Neuroendocrine adenoma of the mouse intestinal tract (NCIt: C22150)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6J double transgenic RIP1Tag2/Rip2pyST1.
Hierarchy Parent: CVCL_J405 (STC-1)
Sex of cell Sex unspecified
Age at sampling 10-13W
Category Cancer cell line
Publications

PubMed=12124779; DOI=10.1002/jcp.10139
Erin B. Ramshur, Teena R. Rull, Burton M. Wice;
Novel insulin/GIP co-producing cell lines provide unexpected insights into gut K-cell function in vivo.
J. Cell. Physiol. 192:339-350(2002)

PubMed=22768997; DOI=10.1016/j.metabol.2012.05.017
Katharine V. Hand, Linda Giblin, Brian D. Green;
Hormone profiling in a novel enteroendocrine cell line pGIP/neo: STC-1.
Metabolism 61:1683-1686(2012)

PubMed=28870797; DOI=10.1016/j.peptides.2017.08.010
Anna L. Gillespie, Xiao-Bei Pan, Anna Marco-Ramell, Caroline Meharg, Brian D. Green;
Detailed characterisation of STC-1 cells and the pGIP/Neo sub-clone suggests the incretin hormones are translationally regulated.
Peptides 96:20-30(2017)

Cross-references
Encyclopedic resources Wikidata; Q116050577
Entry history
Entry creation15-Dec-2022
Last entry update14-Aug-2025
Version number7