| Cell line name |
A673-SLFN11-KO |
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| Accession |
CVCL_C6N5 |
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| Resource Identification Initiative |
To cite this cell line use: A673-SLFN11-KO (RRID:CVCL_C6N5) |
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| Comments |
Problematic cell line: Misclassified. Parent cell line (A-673) was originally thought to be a rhabdomyosarcoma cell line but is an Ewing sarcoma cell line.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:26633; SLFN11.
Derived from site: In situ; Muscle; UBERON=UBERON_0001630. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala119Glnfs*5 (c.353_354dupCA) (c.354_355insCA); Zygosity=Homozygous (from parent cell line).
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| Disease |
Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0080 (A-673) |
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| Sex of cell |
Female |
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| Age at sampling |
15Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=34413129; DOI=10.1158/1535-7163.MCT-21-0089; PMCID=PMC8571037
Jessica Gartrell, Marcia Mellado-Largarde, Michael R. Clay, Armita Bahrami, Natasha A. Sahr, April D. Sykes, Kaley Blankenship, Lauren Hoffmann, Jia Xie, Hyekyung P. Cho, Nathaniel Twarog ...Show all 21 authors... , Michele Connelly, Koon-Kiu Yan, Ji-Yang Yu, Shaina N. Porter, Shondra M. Pruett-Miller, Geoffrey Neale, Christopher L. Tinkle, Sara M. Federico, Elizabeth A. Stewart, Anang A. Shelat; Show fewer authors
SLFN11 is widely expressed in pediatric sarcoma and induces variable sensitization to replicative stress caused by DNA-damaging agents.
Mol. Cancer Ther. 20:2151-2165(2021) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q116048466
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| Entry history |
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| Entry creation | 15-Dec-2022 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 5 |
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