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Cellosaurus GSC-83 (CVCL_C6IZ)

[Text version]
Cell line name GSC-83
Synonyms 83
Accession CVCL_C6IZ
Resource Identification Initiative To cite this cell line use: GSC-83 (RRID:CVCL_C6IZ)
Comments Group: Cancer stem cell line.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Brain, right temporal lobe; UBERON=UBERON_0002809.
Cell type: Mesenchymal stem cell; CL=CL_0000134.
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C6J3 (GSC-83/ALDH1A3-KO.1.2)
Sex of cell Female
Age at sampling 72Y
Category Cancer cell line

PubMed=23650391; DOI=10.1073/pnas.1221478110
Mao P., Joshi K., Li J.-F., Kim S.-H., Li P.-P., Santana-Santos L., Luthra S., Chandran U.R., Benos P.V., Smith L., Wang M.-D., Hu B., Cheng S.-Y., Sobol R.W., Nakano I.
Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3.
Proc. Natl. Acad. Sci. U.S.A. 110:8644-8649(2013)

PubMed=34934174; DOI=10.1038/s42003-021-02949-7
Li J.-F., Garavaglia S., Ye Z.-F., Moretti A., Belyaeva O.V., Beiser A., Ibrahim M., Wilk A., McClellan S., Klyuyeva A.V., Goggans K.R., Kedishvili N.Y., Salter E.A., Wierzbicki A., Migaud M.E., Mullett S.J., Yates N.A., Camacho C.J., Rizzi M., Sobol R.W.
A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells.
Commun. Biol. 4:1420.1-1420.16(2021)

Encyclopedic resources Wikidata; Q116049104
Gene expression databases GEO; GSM1638636
GEO; GSM1638637
GEO; GSM1638638
Entry history
Entry creation15-Dec-2022
Last entry update29-Jun-2023
Version number3