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Cellosaurus GSC-83 (CVCL_C6IZ)

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Cell line name GSC-83
Synonyms 83
Accession CVCL_C6IZ
Resource Identification Initiative To cite this cell line use: GSC-83 (RRID:CVCL_C6IZ)
Comments Group: Cancer stem cell line.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Brain, right temporal lobe; UBERON=UBERON_0002809.
Cell type: Mesenchymal stem cell; CL=CL_0000134.
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C6J3 (GSC-83/ALDH1A3-KO.1.2)
Sex of cell Female
Age at sampling 72Y
Category Cancer cell line
Publications

PubMed=23650391; DOI=10.1073/pnas.1221478110; PMCID=PMC3666732
Ping Mao, Kaushal Joshi, Jian-Feng Li, Sung-Hak Kim, Pei-Pei Li, Lucas Santana-Santos, Soumya Luthra, Uma R. Chandran, Panayiotis V. Benos, Luke Smith, Mao-De Wang ...Show all 15 authors... , Bo Hu, Shi-Yuan Cheng, Robert William Sobol, Ichiro Nakano; Show fewer authors
Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3.
Proc. Natl. Acad. Sci. U.S.A. 110:8644-8649(2013)

PubMed=34934174; DOI=10.1038/s42003-021-02949-7; PMCID=PMC8692581
Jian-Feng Li, Silvia Garavaglia, Zhao-Feng Ye, Andrea Moretti, Olga V. Belyaeva, Alison Beiser, Md Ibrahim, Anna Wilk, Steve McClellan, Alla V. Klyuyeva, Kelli R. Goggans ...Show all 20 authors... , Natalia Y. Kedishvili, E. Alan Salter, Andrzej Wierzbicki, Marie E. Migaud, Steven J. Mullett, Nathan A. Yates, Carlos J. Camacho, Menico Rizzi, Robert William Sobol; Show fewer authors
A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells.
Commun. Biol. 4:1420.1-1420.16(2021)

Cross-references
Encyclopedic resources Wikidata; Q116049104
Gene expression databases GEO; GSM1638636
GEO; GSM1638637
GEO; GSM1638638
Entry history
Entry creation15-Dec-2022
Last entry update10-Apr-2025
Version number4