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Cellosaurus GSC-83 (CVCL_C6IZ)

[Text version]
Cell line name GSC-83
Synonyms 83
Accession CVCL_C6IZ
Resource Identification Initiative To cite this cell line use: GSC-83 (RRID:CVCL_C6IZ)
Comments Group: Cancer stem cell line.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Brain, right temporal lobe; UBERON=UBERON_0002809.
Cell type: Mesenchymal stem cell; CL=CL_0000134.
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C6J3 (GSC-83/ALDH1A3-KO.1.2)
Sex of cell Female
Age at sampling 72Y
Category Cancer cell line
Publications

PubMed=23650391; DOI=10.1073/pnas.1221478110; PMCID=PMC3666732
Mao P., Joshi K., Li J.-F., Kim S.-H., Li P.-P., Santana-Santos L., Luthra S., Chandran U.R., Benos P.V., Smith L., Wang M.-D., Hu B., Cheng S.-Y., Sobol R.W., Nakano I.
Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3.
Proc. Natl. Acad. Sci. U.S.A. 110:8644-8649(2013)

PubMed=34934174; DOI=10.1038/s42003-021-02949-7; PMCID=PMC8692581
Li J.-F., Garavaglia S., Ye Z.-F., Moretti A., Belyaeva O.V., Beiser A., Ibrahim M., Wilk A., McClellan S., Klyuyeva A.V., Goggans K.R., Kedishvili N.Y., Salter E.A., Wierzbicki A., Migaud M.E., Mullett S.J., Yates N.A., Camacho C.J., Rizzi M., Sobol R.W.
A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells.
Commun. Biol. 4:1420.1-1420.16(2021)

Cross-references
Encyclopedic resources Wikidata; Q116049104
Gene expression databases GEO; GSM1638636
GEO; GSM1638637
GEO; GSM1638638
Entry history
Entry creation15-Dec-2022
Last entry update10-Apr-2025
Version number4