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Cellosaurus CC531mdr+ (CVCL_C5RJ)

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Cell line name CC531mdr+
Accession CVCL_C5RJ
Resource Identification Initiative To cite this cell line use: CC531mdr+ (RRID:CVCL_C5RJ)
Comments Characteristics: Multidrug resistant, in addition to colchicine it also is resistant against actinomycin D, daunorubicin, doxorubicin and vinblastine (PubMed=7903965).
Selected for resistance to: ChEBI; CHEBI_23359; Colchicine.
Transformant: ChEBI; CHEBI_73755; 1,2-dimethylhydrazine (DMH).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Disease Adenocarcinoma of the rat colon (NCIt: C63866)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: WAG/Rij; RS=RS_0000969.
Hierarchy Parent: CVCL_0206 (CC531)
Children:
CVCL_C5RK (CC531rev)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=7903965; DOI=10.1111/j.1349-7006.1993.tb02822.x; PMCID=PMC5919088
Eric Gheuens, Sylke van der Heyden, Hilde Elst, Alexander Maximiliaan Marie Eggermont, Allan Theo Van Oosterom, Ernst De Bruijn;
Multidrug resistance in rat colon carcinoma cell lines CC531, CC531mdr+ and CC531rev.
Jpn. J. Cancer Res. 84:1201-1208(1993)

PubMed=14727116; DOI=10.1007/s00424-003-1216-7
Philippe E. Golstein, A. Daifi, Raphael Crutzen, Alain Boom, Willy Van Driessche, Renaud Beauwens;
Hypotonic cell swelling stimulates permeability to cAMP in a rat colonic cell line.
Pflugers Arch. 447:845-854(2004)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL3833761
Encyclopedic resources Wikidata; Q116048692
Entry history
Entry creation15-Dec-2022
Last entry update10-Apr-2025
Version number6