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Cellosaurus mAb158 (CVCL_C4UY)

[Text version]
Cell line name mAb158
Accession CVCL_C4UY
Resource Identification Initiative To cite this cell line use: mAb158 (RRID:CVCL_C4UY)
Comments Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized lecanemab (BAN2401) therapeutic antibody used for the treatmen of Alzheimer disease.
Monoclonal antibody isotype: IgG2a.
Monoclonal antibody target: UniProtKB; P05067; Human APP (Note=Selectively binds to large, soluble Abeta protofibrils, does not bind native APP).
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_2199 (Sp2/0-Ag14)
Category Hybridoma

PubMed=17623042; DOI=10.1111/j.1471-4159.2007.04759.x
Englund H., Sehlin D., Johansson A.-S., Nilsson L.N.G., Gellerfors P., Paulie S., Lannfelt L., Pettersson F.E.
Sensitive ELISA detection of amyloid-beta protofibrils in biological samples.
J. Neurochem. 103:334-345(2007)

Encyclopedic resources Wikidata; Q116049759
Entry history
Entry creation15-Dec-2022
Last entry update21-Mar-2023
Version number2