Cell line name |
T84SF |
Accession |
CVCL_C4S3 |
Resource Identification Initiative |
To cite this cell line use: T84SF (RRID:CVCL_C4S3) |
Comments |
Population: Caucasian. Characteristics: Metastatic. Selected by repetitive plating on TNFalpha-activated human endothelial cells and subsequent selection for adherent cells (PubMed=15484219). Derived from site: Metastatic; Lung; UBERON=UBERON_0002048. |
Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Leu1488Phefs*19 (c.4464delA); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Lys340Asn (c.1020G>C); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; c.560-1G>T; ClinVar=VCV003148249; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
|
Disease |
Colon adenocarcinoma (NCIt: C4349) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0555 (T84) |
Sex of cell |
Male |
Age at sampling |
72Y |
Category |
Cancer cell line |
Publications | PubMed=15484219; DOI=10.1002/jcp.20236 Riccardo Alessandro, Anna Maria Flugy, Domenica Russo, Giorgio Stassi, A. De Leo, Chiara Corrado, Giuseppe Alaimo, Giacomo De Leo; Identification and phenotypic characterization of a subpopulation of T84 human colon cancer cells, after selection on activated endothelial cells. J. Cell. Physiol. 203:261-272(2005) PubMed=16612624; DOI=10.1007/s00428-006-0179-4 Riccardo Alessandro, Maria Antonietta Di Bella, Anna Maria Flugy, Simona Fontana, Francesca Damiani, Chiara Corrado, Paolo Colomba, Matilde Todaro, Domenica Russo, Alessandra Santoro, Elise C. Kohn, Giacomo De Leo; Comparative study of T84 and T84SF human colon carcinoma cells: in vitro and in vivo ultrastructural and functional characterization of cell culture and metastasis. Virchows Arch. 449:48-61(2006) |
Cross-references |
Encyclopedic resources |
Wikidata; Q116050626
|
Entry history |
Entry creation | 15-Dec-2022 |
Last entry update | 10-Apr-2025 |
Version number | 5 |
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