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Cellosaurus T84SF (CVCL_C4S3)

[Text version]
Cell line name T84SF
Accession CVCL_C4S3
Resource Identification Initiative To cite this cell line use: T84SF (RRID:CVCL_C4S3)
Comments Population: Caucasian.
Characteristics: Metastatic. Selected by repetitive plating on TNFA-activated human endothelial cells and subsequent selection for adherent cells (PubMed=15484219).
Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Leu1488Phefs*19 (c.4464delA); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Lys340Asn (c.1020G>C); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.560-1G>T; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0555 (T84)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line

PubMed=15484219; DOI=10.1002/jcp.20236
Alessandro R., Flugy A.M., Russo D., Stassi G., De Leo A., Corrado C., Alaimo G., De Leo G.
Identification and phenotypic characterization of a subpopulation of T84 human colon cancer cells, after selection on activated endothelial cells.
J. Cell. Physiol. 203:261-272(2005)

PubMed=16612624; DOI=10.1007/s00428-006-0179-4
Alessandro R., Di Bella M.A., Flugy A.M., Fontana S., Damiani F., Corrado C., Colomba P., Todaro M., Russo D., Santoro A., Kohn E.C., De Leo G.
Comparative study of T84 and T84SF human colon carcinoma cells: in vitro and in vivo ultrastructural and functional characterization of cell culture and metastasis.
Virchows Arch. 449:48-61(2006)

Encyclopedic resources Wikidata; Q116050626
Entry history
Entry creation15-Dec-2022
Last entry update29-Jun-2023
Version number3