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Cellosaurus T84SF (CVCL_C4S3)

[Text version]
Cell line name T84SF
Accession CVCL_C4S3
Resource Identification Initiative To cite this cell line use: T84SF (RRID:CVCL_C4S3)
Comments Population: Caucasian.
Characteristics: Metastatic. Selected by repetitive plating on TNFalpha-activated human endothelial cells and subsequent selection for adherent cells (PubMed=15484219).
Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Leu1488Phefs*19 (c.4464delA); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Lys340Asn (c.1020G>C); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.560-1G>T; ClinVar=VCV003148249; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0555 (T84)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
Publications

PubMed=15484219; DOI=10.1002/jcp.20236
Riccardo Alessandro, Anna Maria Flugy, Domenica Russo, Giorgio Stassi, A. De Leo, Chiara Corrado, Giuseppe Alaimo, Giacomo De Leo;
Identification and phenotypic characterization of a subpopulation of T84 human colon cancer cells, after selection on activated endothelial cells.
J. Cell. Physiol. 203:261-272(2005)

PubMed=16612624; DOI=10.1007/s00428-006-0179-4
Riccardo Alessandro, Maria Antonietta Di Bella, Anna Maria Flugy, Simona Fontana, Francesca Damiani, Chiara Corrado, Paolo Colomba, Matilde Todaro, Domenica Russo, Alessandra Santoro, Elise C. Kohn, Giacomo De Leo;
Comparative study of T84 and T84SF human colon carcinoma cells: in vitro and in vivo ultrastructural and functional characterization of cell culture and metastasis.
Virchows Arch. 449:48-61(2006)

Cross-references
Encyclopedic resources Wikidata; Q116050626
Entry history
Entry creation15-Dec-2022
Last entry update10-Apr-2025
Version number5