ID   T84SF
AC   CVCL_C4S3
DR   Wikidata; Q116050626
RX   PubMed=15484219;
RX   PubMed=16612624;
CC   Population: Caucasian.
CC   Characteristics: Metastatic. Selected by repetitive plating on TNFA-activated human endothelial cells and subsequent selection for adherent cells (PubMed=15484219).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Leu1488Phefs*19 (c.4464delA); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Lys340Asn (c.1020G>C); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.560-1G>T; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
CC   Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0555 ! T84
SX   Male
AG   72Y
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 29-06-23; Version: 3
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RX   PubMed=15484219; DOI=10.1002/jcp.20236;
RA   Alessandro R., Flugy A.M., Russo D., Stassi G., De Leo A., Corrado C.,
RA   Alaimo G., De Leo G.;
RT   "Identification and phenotypic characterization of a subpopulation of
RT   T84 human colon cancer cells, after selection on activated endothelial
RT   cells.";
RL   J. Cell. Physiol. 203:261-272(2005).
//
RX   PubMed=16612624; DOI=10.1007/s00428-006-0179-4;
RA   Alessandro R., Di Bella M.A., Flugy A.M., Fontana S., Damiani F.,
RA   Corrado C., Colomba P., Todaro M., Russo D., Santoro A., Kohn E.C.,
RA   De Leo G.;
RT   "Comparative study of T84 and T84SF human colon carcinoma cells: in
RT   vitro and in vivo ultrastructural and functional characterization of
RT   cell culture and metastasis.";
RL   Virchows Arch. 449:48-61(2006).
//