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Cellosaurus VeroE6-Pgp-KO (CVCL_C4RQ)

[Text version]
Cell line name VeroE6-Pgp-KO
Accession CVCL_C4RQ
Resource Identification Initiative To cite this cell line use: VeroE6-Pgp-KO (RRID:CVCL_C4RQ)
Comments Group: Non-human primate cell line.
Group: SARS-CoV-2 research cell line.
Virology: Can be used for in vitro virus infection system for SARS-CoV-2 and possibly other viruses to test antiviral therapies without a need to control the ABCB1/Pgp efflux transporter activity (PubMed=36208677).
Knockout cell: Method=CRISPR/Cas9; UniProtKB; A0A0D9RIY5; ABCB1.
Derived from site: In situ; Kidney, epithelium; UBERON=UBERON_0004819.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) (NCBI Taxonomy: 60711)
Hierarchy Parent: CVCL_0574 (Vero C1008)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=36208677; DOI=10.1016/j.antiviral.2022.105429
Zhu Y., Binder J., Yurgelonis I., Rai D.K., Lazarro S., Costales C., Kobylarz K., McMonagle P., Steppan C.M., Aschenbrenner L., Anderson A.S., Cardin R.D.
Generation of a VeroE6 Pgp gene knock out cell line and its use in SARS-CoV-2 antiviral study.
Antiviral Res. 208:105429.1-105429.6(2022)

Cross-references
Encyclopedic resources Wikidata; Q116050765
Entry history
Entry creation15-Dec-2022
Last entry update05-Oct-2023
Version number4