ID   VeroE6-Pgp-KO
AC   CVCL_C4RQ
DR   Wikidata; Q116050765
RX   PubMed=36208677;
CC   Group: Non-human primate cell line.
CC   Group: SARS-CoV-2 research cell line.
CC   Virology: Can be used for in vitro virus infection system for SARS-CoV-2 and possibly other viruses to test antiviral therapies without a need to control the ABCB1/Pgp efflux transporter activity (PubMed=36208677).
CC   Knockout cell: Method=CRISPR/Cas9; UniProtKB; A0A0D9RIY5; ABCB1.
CC   Derived from site: In situ; Kidney, epithelium; UBERON=UBERON_0004819.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
OX   NCBI_TaxID=60711; ! Chlorocebus sabaeus (Green monkey)
HI   CVCL_0574 ! Vero C1008
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 15-12-22; Last updated: 05-10-23; Version: 4
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RX   PubMed=36208677; DOI=10.1016/j.antiviral.2022.105429; PMCID=PMC9533647;
RA   Zhu, Yuao
RA   Binder, Joe
RA   Yurgelonis, Irina
RA   Rai, Devendra K.
RA   Lazarro, Sarah
RA   Costales, Chester
RA   Kobylarz, Keith
RA   McMonagle, Patricia
RA   Steppan, Claire M.
RA   Aschenbrenner, Lisa
RA   Anderson, Annaliesa S.
RA   Cardin, Rhonda D.
RT   "Generation of a VeroE6 Pgp gene knock out cell line and its use in
RT   SARS-CoV-2 antiviral study.";
RL   Antiviral Res. 208:105429.1-105429.6(2022).
//