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Cellosaurus AC-10 (CVCL_C4MC)

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Cell line name AC-10
Accession CVCL_C4MC
Resource Identification Initiative To cite this cell line use: AC-10 (RRID:CVCL_C4MC)
Comments Doubling time: ~24 hours (Note=In the presence of 20 ng/ml FGF2), ~48 hours (Note=Without FGF2) (PubMed=9426306).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen (Note=With p.Leu156_Thr708del = Truncated).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Embryonic brain, mesencephalon; UBERON=UBERON_0009616.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Sprague Dawley; RS=RS_0000681.
Sex of cell Sex unspecified
Age at sampling 14FD
Category Transformed cell line
Publications

PubMed=9426306; DOI=10.1007/s004410050989
Mary Ellen Truckenmiller, Carlo Tornatore, Renee Darnell Wright, Ora Dillon-Carter, Sally Meiners, Herbert M. Geller, William J. Freed;
A truncated SV40 large T antigen lacking the p53 binding domain overcomes p53-induced growth arrest and immortalizes primary mesencephalic cells.
Cell Tissue Res. 291:175-189(1998)

Cross-references
Encyclopedic resources Wikidata; Q116048470
Entry history
Entry creation15-Dec-2022
Last entry update14-Aug-2025
Version number6