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Cellosaurus T47D/XBP1 (CVCL_C4MA)

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Cell line name T47D/XBP1
Accession CVCL_C4MA
Resource Identification Initiative To cite this cell line use: T47D/XBP1 (RRID:CVCL_C4MA)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:12801; XBP1.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu194Phe (c.580C>T); ClinVar=VCV000127817; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0553 (T-47D)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=17660348; DOI=10.1096/fj.06-7990com
Bianca P. Gomez, Rebecca B. Riggins, Ayesha N. Shajahan, Uwe Klimach, Ai-Fen Wang, Anatasha C. Crawford, Yue-Lin Zhu, Alan Zwart, Ming-Yue Wang, Robert Clarke;
Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines.
FASEB J. 21:4013-4027(2007)

Cross-references
Encyclopedic resources Wikidata; Q116050610
Entry history
Entry creation15-Dec-2022
Last entry update14-Aug-2025
Version number7