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Cellosaurus (CVCL_C4KX)

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Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=4864103; PubMed=5641128; PubMed=1246601; PubMed=20143388). Originally thought to originate from an epidermal carcinoma of the mouth.
Part of: KuDOS 95 cell line panel.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00010.
Population: African American.
Doubling time: ~30 hours (DSMZ=ACC-136).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Genomics; Whole genome sequencing; Low read coverage.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3596; CCRID=1101HUM-PUMC000163; CLS=300446; DSMZ=ACC-136; JCRB=JCRB9027; KCLB=10017; PubMed=11416159; PubMed=17254797; TKG=TKG 0401

Markers:
AmelogeninX
CSF1PO9,10
D13S31712,13.3 (ATCC=CRL-3596; CLS=300446; DSMZ=ACC-136; JCRB=JCRB9027; KCLB=10017; TKG=TKG 0401)
12,14 (CCRID=1101HUM-PUMC000163; PubMed=17254797)
D16S5399,10
D18S5116
D19S43313,14
D21S1127,28
D2S133817
D3S135815,18
D5S81811,12
D7S8208,12
D8S117912,13
FGA21
Penta D8,15
Penta E7,17
TH017
TPOX8,12
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/k/cell-lines-detail-494.html
Publications








Anthony Joseph Girardi, Joel Warren, Cynthia Goldman, Barbara Jeffries;
Growth and CF antigenicity of measles virus in cells deriving from human heart.
Proc. Soc. Exp. Biol. Med. 98:18-22(1958)



hamster.
Science 137:986-987(1962)




Cancer Res. 27:2483-2488(1967)


Bruce Millring Boman, Matilde Olive, Seema Untawale, Mark Blick, Susan North, Gary E. Gallick, Gaudenz Dolf, Michael Joseph Siciliano, Leor David Roubein, Herbert Fritche, Gilles Thomas ...Show all 14 authors... , Sen Pathak, David M. Wildrick, Bernard Levin; Show fewer authors
The DiFi rectal carcinoma cell line from a familial adenomatous polyposis patient: an in vitro model system to study genetic changes in colorectal cancer.
(In book chapter) Hereditary colorectal cancer; Utsunomiya, Joji & Lynch, Henry Thompson (eds.); pp.541-548; Springer; Tokyo; Japan (1990)




Immunology 78:364-370(1993)


M. Rocio A. Carrera, Jon A. Ashley, Bin Zhou, Peter Wirsching, George F. Koob, Kim David Janda;
Cocaine vaccines: antibody protection against relapse in a rat model.
Proc. Natl. Acad. Sci. U.S.A. 97:6202-6206(2000)


Rahima Zennadi, Zeinab Abdel-Wahab, Hilliard Foster Seigler, Timothy L. Darrow;
Generation of melanoma-specific, cytotoxic CD4(+) T helper 2 cells: requirement of both HLA-DR15 and Fas antigens on melanomas for their lysis by Th2 cells.
Cell. Immunol. 210:96-105(2001)




Oncogene 25:2181-2191(2006)




Int. J. Cancer 122:2719-2725(2008)



stimulates proliferation of ovine trophectoderm cells through MTOR-RPS6K-RPS6 signaling cascade and synthesis of nitric oxide and polyamines.
Biol. Reprod. 84:70-78(2011)


Wendell A. Lim;
Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells.
Nature 488:384-388(2012)


Stephen M. Hewitt, Lars Zender, Veena Kapoor, Dean W. Felsher, Michael Peter Manns, Firouzeh Korangy, Tim F. Greten;
Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma.
J. Hepatol. 59:1007-1013(2013)



growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer.
Sci. Transl. Med. 5:216ra177.1-216ra177.10(2013)



Distinct electrophysiological and mechanical beating phenotypes of long QT syndrome type 1-specific cardiomyocytes carrying different mutations.
Int. J. Cardiol. Heart Vasc. 8:19-31(2015)


Giulia Bertolini, Lucia D'Amico, Massimo Moro, Elena Landoni, Paola Perego, Rosalba Miceli, Laura Gatti, Francesca Andriani, Donald Wong, Roberto Caserini, Monica Tortoreto ...Show all 18 authors... , Massimo Milione, Riccardo Ferracini, Luigi Mariani, Ugo Pastorino, Ilaria Roato, Gabriella Sozzi, Luca Roz; Show fewer authors
Microenvironment-modulated metastatic CD133+/CXCR4+/EpCAM- lung cancer-initiating cells sustain tumor dissemination and correlate with poor prognosis.
Cancer Res. 75:3636-3649(2015)


Bao-Long Xia, Gabriel Amador, Raghuvir Viswanatha, Jonathan D. Zirin, Stephanie E. Mohr, Norbert Perrimon;
CRISPR-based engineering of gene knockout cells by homology-directed insertion in polyploid Drosophila S2R+ cells.
Nat. Protoc. 15:3478-3498(2020)


Miyuki Kawase, Shinji Saito, Ikuyo Takayama, Noriyo Nagata, Tsuyoshi Sekizuka, Hiroshi Katoh, Fumihiro Kato, Masafumi Sakata, Maino Tahara, Satoshi Kutsuna, Norio Ohmagari ...Show all 15 authors... , Makoto Kuroda, Tadaki Suzuki, Tsutomu Kageyama, Makoto Takeda; Show fewer authors
Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells.
Proc. Natl. Acad. Sci. U.S.A. 117:7001-7003(2020)


Makoto Kuroda, Tadaki Suzuki, Tsutomu Kageyama, Makoto Takeda;
Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells.
Proc. Natl. Acad. Sci. U.S.A. 117:7001-7003(2020)


Geraldine Goh, Matae Ahn, Feng Zhu, Lim Beng Lee, Da-Hai Luo, Aaron T. Irving, Lin-Fa Wang;
Complementary regulation of caspase-1 and IL-1beta reveals additional mechanisms of dampened inflammation in bats.
Proc. Natl. Acad. Sci. U.S.A. 117:28939-28949(2020)



resistance mechanisms -- an in vitro study.
Biomedicines 12:1412.1-1412.13(2024)

Cross-references
Cell line collections (Providers) ATCC; CRL-3596
BCRC; 60017 - Discontinued
BCRJ; 0128
CCLV; CCLV-RIE 0016
CLS; 300446
DSMZ; ACC-136 - Discontinued
ECACC; 86103004 - Discontinued
ECACC; 94050408
ICLC; HTL96014 - Discontinued
IZSLER; BS TCL 34
JCRB; JCRB9027
KCB; KCB 94020YJ
KCLB; 10017
NCBI_Iran; C152
RCB; RCB1888 - Discontinued
TKG; TKG 0401
Cell line databases/resources CCRID; 1101HUM-PUMC000163
DSMZCellDive; ACC-136
TOKU-E; 2094
Biological sample resources BioSample; SAMN03151730
Chemistry resources ChEMBL-Cells; CHEMBL3307959
ChEMBL-Targets; CHEMBL398
PubChem_Cell_line; CVCL_0372
Encyclopedic resources Wikidata; Q28334825
Gene expression databases GEO; GSM1374595
GEO; GSM1374596
Medical resources MeSH; D007624
Polymorphism and mutation databases Cosmic; 753567
Cosmic; 1042301
Cosmic; 1339927
Cosmic; 1969496
Cosmic; 2301581
Cosmic; 2546843
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number42