Cellosaurus cell line CuFi-4 (CVCL

Cellosaurus CuFi-4 (CVCL_C459)

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Cell line name

CuFi-4

Synonyms

Cystic Fibrosis, University of Iowa-4

Accession

CVCL_C459

Resource Identification Initiative

To cite this cell line use: CuFi-4 (RRID:CVCL_C459)

Comments

Karyotypic information: 48,XX,+5,+20 [10] (PubMed=12676769).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.

Sequence variations

Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Heterozygous (PubMed=12676769).
Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Gly551Asp (c.1652G>A); ClinVar=VCV000007120; Zygosity=Heterozygous (PubMed=12676769).

Disease

Cystic fibrosis (NCIt: C2975)
Cystic fibrosis (ORDO: Orphanet_586)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

33Y

Category

Transformed cell line

STR profile

Source(s): ATCC=CRL-4015

Markers:

Amelogenin	X
CSF1PO	13
D2S1338	20,23
D3S1358	14,18
D5S818	11,13
D7S820	10,12
D8S1179	11,14
D13S317	11,12
D16S539	12,13
D18S51	14,15
D19S433	14,15
D21S11	29,30
FGA	21,24
Penta D	12
Penta E	12,17
TH01	7
TPOX	8,11
vWA	17,18

Publications

PubMed=12676769; DOI=10.1152/ajplung.00355.2002
Joseph Zabner, Phil Karp, Michael Seiler, Stacia L. Phillips, Calista J. Mitchell, Mimi T. Saavedra, Michael James Welsh, Aloysius J. Klingelhutz;
Development of cystic fibrosis and noncystic fibrosis airway cell lines.
Am. J. Physiol. Lung Cell. Mol. Physiol. 284:L844-L854(2003)

Cross-references

Cell line collections (Providers)

ATCC; CRL-4015
CancerTools; 154447

Biological sample resources

BioSample; SAMN03471724

Encyclopedic resources

Wikidata; Q54814857

Entry history

Entry creation

22-Oct-2012

Last entry update

14-Aug-2025

Version number