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Cellosaurus PK15S10 (CVCL_C3VI)

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Cell line name PK15S10
Synonyms PK15(S10); PK-15S10+; PK-15(S10+); PK-15 Siglec-10
Accession CVCL_C3VI
Resource Identification Initiative To cite this cell line use: PK15S10 (RRID:CVCL_C3VI)
Comments Virology: Highly susceptible to infection by porcine reproductive and respiratory syndrome (PRRSV).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection/transduction; Gene=VGNC; VGNC:112760; Pig SIGLEC10.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Species of origin Sus scrofa (Pig) (NCBI Taxonomy: 9823)
Breed/subspecies: Hampshire; VBO=VBO_0001146.
Hierarchy Parent: CVCL_2160 (PK-15)
Children:
CVCL_C3VJ (PK15S10-CD163)
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=28742001; DOI=10.1099/jgv.0.000859; PMCID=PMC5656783
Jie-Xiong Xie, Isaura Christiaens, Bo Yang, Wander Van Breedam, Ting-Ting Cui, Hans J. Nauwynck;
Molecular cloning of porcine Siglec-3, Siglec-5 and Siglec-10, and identification of Siglec-10 as an alternative receptor for porcine reproductive and respiratory syndrome virus (PRRSV).
J. Gen. Virol. 98:2030-2042(2017)

PubMed=30021620; DOI=10.1186/s13567-018-0569-z; PMCID=PMC6052533
Jie-Xiong Xie, Isaura Christiaens, Bo Yang, Ivan Trus, Bert Devriendt, Ting-Ting Cui, Rui-Fang Wei, Hans J. Nauwynck;
Preferential use of Siglec-1 or Siglec-10 by type 1 and type 2 PRRSV strains to infect PK15(S1-CD163) and PK15(S10-CD163) cells.
Vet. Res. 49:67.1-67.13(2018)

Cross-references
Encyclopedic resources Wikidata; Q116050122
Entry history
Entry creation15-Dec-2022
Last entry update14-Aug-2025
Version number7