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Cellosaurus 3.19.3 (CVCL_C3S6)

[Text version]
Cell line name 3.19.3
Accession CVCL_C3S6
Resource Identification Initiative To cite this cell line use: 3.19.3 (RRID:CVCL_C3S6)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-7260.
Monoclonal antibody isotype: IgG2, kappa.
Monoclonal antibody target: UniProtKB; O15123; Human ANGPT2 (Note=Also reacts with mouse).
Miscellaneous: As the immunized splenic B-cells are from Xenomouse mice the produced mAB is of human origin.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_4032 (P3X63Ag8.653)
Category Hybridoma
Publications

PubMed=20053776; DOI=10.1158/1535-7163.MCT-09-0554
Brown J.L., Cao Z.A., Pinzon-Ortiz M., Kendrew J., Reimer C., Wen S.-H., Zhou J.Q., Tabrizi M., Emery S.C., McDermott B., Pablo L., McCoon P., Bedian V., Blakey D.C.
A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical models.
Mol. Cancer Ther. 9:145-156(2010)

Patent=US10066011
Green L.L., Zhou Q., Keyt B.A., Yang X.-D., Emery S.C., Blakey D.C.
Antibodies directed to angiopoietin-2 and uses thereof.
Patent number US10066011, 04-Sep-2018

Cross-references
Cell line collections (Providers) ATCC; PTA-7260
Biological sample resources ABCD; ABCD_AS321
Encyclopedic resources Wikidata; Q116048090
Entry history
Entry creation15-Dec-2022
Last entry update21-Mar-2023
Version number2