ID   3.19.3
AC   CVCL_C3S6
DR   ABCD; ABCD_AS321
DR   ATCC; PTA-7260
DR   Wikidata; Q116048090
RX   Patent=US10066011;
RX   PubMed=20053776;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-7260.
CC   Monoclonal antibody isotype: IgG2, kappa.
CC   Monoclonal antibody target: UniProtKB; O15123; Human ANGPT2 (Note=Also reacts with mouse).
CC   Miscellaneous: As the immunized splenic B-cells are from Xenomouse mice the produced mAB is of human origin.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_4032 ! P3X63Ag8.653
CA   Hybridoma
DT   Created: 15-12-22; Last updated: 21-03-23; Version: 2
//
RX   Patent=US10066011;
RA   Green L.L., Zhou Q., Keyt B.A., Yang X.-D., Emery S.C., Blakey D.C.;
RT   "Antibodies directed to angiopoietin-2 and uses thereof.";
RL   Patent number US10066011, 04-Sep-2018.
//
RX   PubMed=20053776; DOI=10.1158/1535-7163.MCT-09-0554;
RA   Brown J.L., Cao Z.A., Pinzon-Ortiz M., Kendrew J., Reimer C., Wen S.-H.,
RA   Zhou J.Q., Tabrizi M., Emery S.C., McDermott B., Pablo L., McCoon P.,
RA   Bedian V., Blakey D.C.;
RT   "A human monoclonal anti-ANG2 antibody leads to broad antitumor
RT   activity in combination with VEGF inhibitors and chemotherapy agents
RT   in preclinical models.";
RL   Mol. Cancer Ther. 9:145-156(2010).
//