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Cellosaurus WM115-RAGE (CVCL_C3N7)

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Cell line name WM115-RAGE
Accession CVCL_C3N7
Resource Identification Initiative To cite this cell line use: WM115-RAGE (RRID:CVCL_C3N7)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:320; AGER.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Right anterior leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Asp (c.1799_1800delTGinsAT); ClinVar=VCV000375939; Zygosity=Heterozygous (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0040 (WM115)
Sex of cell Female
Age at sampling 55Y
Category Cancer cell line
Publications

PubMed=24613454; DOI=10.1016/j.bbadis.2014.02.013
Varsha Meghnani, Stefan W. Vetter, Estelle Leclerc;
RAGE overexpression confers a metastatic phenotype to the WM115 human primary melanoma cell line.
Biochim. Biophys. Acta 1842:1017-1027(2014)

PubMed=25310905; DOI=10.1016/j.biocel.2014.10.001
Varsha Meghnani, Anil Wagh, Venkata Shravan K. Indurthi, Mohit Koladia, Stefan W. Vetter, Benedict Law, Estelle Leclerc;
The receptor for advanced glycation end products influences the expression of its S100 protein ligands in melanoma tumors.
Int. J. Biochem. Cell Biol. 57:54-62(2014)

Cross-references
Cell line collections (Providers) ABM; T6013
Encyclopedic resources Wikidata; Q116050797
Entry history
Entry creation15-Dec-2022
Last entry update14-Aug-2025
Version number6