ID   WM115-RAGE
AC   CVCL_C3N7
DR   ABM; T6013
DR   Wikidata; Q116050797
RX   PubMed=24613454;
RX   PubMed=25310905;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 9588; PTEN; Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Asp (c.1799_1800delTGinsAT); ClinVar=VCV000375939; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 320; AGER.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: Metastatic; Right anterior leg, skin; UBERON=UBERON_0001511.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0040 ! WM115
SX   Female
AG   55Y
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 29-06-23; Version: 3
//
RX   PubMed=24613454; DOI=10.1016/j.bbadis.2014.02.013;
RA   Meghnani V., Vetter S.W., Leclerc E.;
RT   "RAGE overexpression confers a metastatic phenotype to the WM115 human
RT   primary melanoma cell line.";
RL   Biochim. Biophys. Acta 1842:1017-1027(2014).
//
RX   PubMed=25310905; DOI=10.1016/j.biocel.2014.10.001;
RA   Meghnani V., Wagh A., Indurthi V.S.K., Koladia M., Vetter S.W., Law B.,
RA   Leclerc E.;
RT   "The receptor for advanced glycation end products influences the
RT   expression of its S100 protein ligands in melanoma tumors.";
RL   Int. J. Biochem. Cell Biol. 57:54-62(2014).
//