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Cellosaurus WM115-MOCK (CVCL_C3N6)

[Text version]
Cell line name WM115-MOCK
Accession CVCL_C3N6
Resource Identification Initiative To cite this cell line use: WM115-MOCK (RRID:CVCL_C3N6)
Comments Population: Caucasian.
Characteristics: Control cell line for WM115-RAGE (Cellosaurus=CVCL_C3N7). Transfected with an empty pcDNA3 vector.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: Metastatic; Right anterior leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 9588; PTEN; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Asp (c.1799_1800delTGinsAT); ClinVar=VCV000375939; Zygosity=Heterozygous (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0040 (WM115)
Sex of cell Female
Age at sampling 55Y
Category Cancer cell line
Publications

PubMed=24613454; DOI=10.1016/j.bbadis.2014.02.013
Meghnani V., Vetter S.W., Leclerc E.
RAGE overexpression confers a metastatic phenotype to the WM115 human primary melanoma cell line.
Biochim. Biophys. Acta 1842:1017-1027(2014)

PubMed=25310905; DOI=10.1016/j.biocel.2014.10.001
Meghnani V., Wagh A., Indurthi V.S.K., Koladia M., Vetter S.W., Law B., Leclerc E.
The receptor for advanced glycation end products influences the expression of its S100 protein ligands in melanoma tumors.
Int. J. Biochem. Cell Biol. 57:54-62(2014)

Cross-references
Encyclopedic resources Wikidata; Q116050796
Entry history
Entry creation15-Dec-2022
Last entry update29-Jun-2023
Version number3