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Cellosaurus MV-4-11B (CVCL_C3HG)

[Text version]
Cell line name MV-4-11B
Synonyms MV-4-11-B; MV-4-11b
Accession CVCL_C3HG
Resource Identification Initiative To cite this cell line use: MV-4-11B (RRID:CVCL_C3HG)
Comments Population: Caucasian.
Omics: BRD4 ChIP-seq epigenome analysis.
Omics: Pol2 ChIP-seq epigenome analysis.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 7135; AFF1 + HGNC; 7132; KMT2A; Name(s)=KMT2A-AFF1, MLL-AFF1, ALL-1/AF4 (from parent cell line).
  • Mutation; HGNC; 3765; FLT3; Unexplicit; Internal tandem duplication (FLT3-ITD); ClinVar=VCV000016270; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Heterozygous (PubMed=29491412; PubMed=29454094).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0064 (MV4-11)
Sex of cell Male
Age at sampling 10Y
Category Cancer cell line
Publications

PubMed=29491412; DOI=10.1038/s41388-018-0150-2
Gerlach D., Tontsch-Grunt U., Baum A., Popow J., Scharn D., Hofmann M.H., Engelhardt H., Kaya O., Beck J., Schweifer N., Gerstberger T., Zuber J., Savarese F., Kraut N.
The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML.
Oncogene 37:2687-2701(2018)

PubMed=29454094; DOI=10.1016/j.canlet.2018.02.018
Tontsch-Grunt U., Rudolph D., Waizenegger I.C., Baum A., Gerlach D., Engelhardt H., Wurm M., Savarese F., Schweifer N., Kraut N.
Synergistic activity of BET inhibitor BI 894999 with PLK inhibitor volasertib in AML in vitro and in vivo.
Cancer Lett. 421:112-120(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C3HG
Encyclopedic resources Wikidata; Q114312330
Gene expression databases GEO; GSE103068
GEO; GSM2716693
GEO; GSM2716694
GEO; GSM2716695
GEO; GSM2716696
GEO; GSM2716697
GEO; GSM2716698
GEO; GSM2716699
GEO; GSM2716700
GEO; GSM2716701
GEO; GSM2716702
GEO; GSM2716703
GEO; GSM2716704
GEO; GSM2716705
GEO; GSM2716706
GEO; GSM2716707
GEO; GSM2716713
GEO; GSM2716714
GEO; GSM2716715
GEO; GSM2716716
GEO; GSM2716717
GEO; GSM2716718
GEO; GSM2716719
GEO; GSM2716720
GEO; GSM2716721
GEO; GSM2716722
GEO; GSM2716723
GEO; GSM2716724
GEO; GSM2716725
GEO; GSM2716726
GEO; GSM2716727
GEO; GSM2716728
GEO; GSM2716729
GEO; GSM2716730
GEO; GSM2716731
GEO; GSM2716732
GEO; GSM2716733
GEO; GSM2716734
GEO; GSM2716735
GEO; GSM2716736
GEO; GSM2716737
GEO; GSM2716738
GEO; GSM2716739
GEO; GSM2716752
GEO; GSM2716753
GEO; GSM2716754
GEO; GSM2716755
GEO; GSM2716756
GEO; GSM2716757
GEO; GSM2716758
GEO; GSM2716759
GEO; GSM2716760
GEO; GSM2716761
GEO; GSM2716762
GEO; GSM2716763
GEO; GSM2716764
GEO; GSM2716765
GEO; GSM2716766
GEO; GSM2716767
GEO; GSM2716768
GEO; GSM2716769
GEO; GSM2832581
GEO; GSM2832582
GEO; GSM2832583
GEO; GSM2832584
GEO; GSM2832585
GEO; GSM2832586
GEO; GSM2832587
GEO; GSM2832588
GEO; GSM2832589
GEO; GSM2832590
GEO; GSM2832591
GEO; GSM2832592
GEO; GSM2832593
GEO; GSM2832594
Entry history
Entry creation22-Sep-2022
Last entry update05-Oct-2023
Version number5