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Cellosaurus MV4-11 (CVCL_0064)

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Cell line name MV4-11
Synonyms MV-4-11; MV-4:11; MV4:11; MV 4;11; MV4;11; MV411; MV(4;11); MV4II
Accession CVCL_0064
Resource Identification Initiative To cite this cell line use: MV4-11 (RRID:CVCL_0064)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9591.
Population: Caucasian.
Characteristics: CSF2 and IL3 dependent.
Doubling time: 32 hours (PubMed=25984343); ~48 hours (CLS=300295); ~50 hours (DSMZ=ACC-102).
Karyotypic information: 48,XY,t(4;11)(q21;q23),+8,+19 (ATCC=CRL-9591).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics; PTM; Acetylation.
Omics: Proteomics; PTM; Phosphorylation; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*03:01,68:01
HLA-BB*14:02,18:01
HLA-CC*08:02,15:02
Class II
HLA-DQDQA1*01:02,01:02
DQB1*06:05,06:05
HLA-DRDRB1*01:01,13:02

Source: CLS=300295
Class I
HLA-AA*03:01:01,20:01:02
HLA-BB*14:02:01,18:01:01
HLA-CC*08:02:01,15:02:01
Class II
HLA-DPDPB1*02:01,04:01
HLA-DQDQA1*01:01:01,01:02:01
DQB1*05:01:01,06:09:01
HLA-DRDRB1*01:01:01,13:02:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.59
Native American0
East Asian, North0.34
East Asian, South0
South Asian2.57
European, North67.58
European, South28.91
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C3HG (MV-4-11B)
Sex of cell Male
Age at sampling 10Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0003025/4955; ATCC=CRL-9591; CLS=300295; COG; Cosmic-CLP=908156; DSMZ=ACC-102; PubMed=20922763; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133824,25
D3S135816,17
D5S81811,12
D7S8208,9
D8S117913
D13S31713
D16S53911,12
D18S5111,17
D19S43315
D21S1132 (DSMZ=ACC-102)
32,32.2 (ATCC=CRL-9591; CLS=300295; COG; PubMed=25877200)
32.2 (PubMed=20922763)
FGA19,21
Penta D9,10
Penta E7,18
TH018,9.3
TPOX8,11
vWA14,15

Run an STR similarity search on this cell line
Web pages Info; -; -; https://web.archive.org/web/20201109215324/www.infarktforschung.de/macrophages_cell_lines.html
Publications

PubMed=3496132; DOI=10.1182/blood.V70.1.192.192
Beverly Lange, Mauro Valtieri, Daniela Santoli, Daniele Caracciolo, Fulvio Mavilio, Ingrid Gemperlein, Constance A. Griffin, Beverly S. Emanuel, Janet Finan, Peter Carey Nowell, Giovanni Rovera;
Growth factor requirements of childhood acute leukemia: establishment of GM-CSF-dependent cell lines.
Blood 70:192-199(1987)

PubMed=2656885; DOI=10.1002/stem.5530070202
James N. Ihle, David Askew;
Origins and properties of hematopoietic growth factor-dependent cell lines.
Int. J. Cell Cloning 7:68-91(1989)

PubMed=1423625; DOI=10.1016/0092-8674(92)90603-A
Yan-Song Gu, Tatsuya Nakamura, Hansjuerg Alder, Rajendra Prasad, Ora Canaani, Giuseppe Cimino, Carlo Maria Croce, Eli Canaani;
The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene.
Cell 71:701-708(1992)

PubMed=8353274; DOI=10.1182/blood.V82.4.1080.1080
Chien-Shing Chen, Joanne M. Hilden, Joy Frestedt, Peter H. Domer, Roderick Moore, Stanley Joel Korsmeyer, John H. Kersey;
The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia.
Blood 82:1080-1085(1993)

PubMed=8358709
Joanne M. Hilden, Chien-Shing Chen, Roderick Moore, Joy Frestedt, John H. Kersey;
Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the polymerase chain reaction in t(4;11) acute leukemia.
Cancer Res. 53:3853-3856(1993)

PubMed=9195772; DOI=10.1016/s0925-5710(96)00563-4
Kaoru Tohyama;
Human factor-dependent leukemia cell lines.
Int. J. Hematol. 65:309-317(1997)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=12529668; DOI=10.1038/sj.leu.2402740
Hilmar Quentmeier, Julia Reinhardt, Margarete Zaborski, Hans Gunther Drexler;
FLT3 mutations in acute myeloid leukemia cell lines.
Leukemia 17:120-124(2003)

PubMed=14504097; DOI=10.1182/blood-2003-02-0418
Takeshi Taketani, Tomohiko Taki, Kanji Sugita, Yoshiyuki Furuichi, Eiichi Ishii, Ryoji Hanada, Masahiro Tsuchida, Kenichi Sugita, Kohmei Ida, Yasuhide Hayashi;
FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.
Blood 103:1085-1088(2004)

PubMed=14671638; DOI=10.1038/sj.leu.2403236
Hans Gunther Drexler, Hilmar Quentmeier, Roderick A.F. MacLeod;
Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.
Leukemia 18:227-232(2004)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Anna K. Hagstrom-Andersson, Patrik Eden, David Lindgren, Jens Nilsson, Carin Lassen, Jesper Heldrup, Magnus Fontes, Ake Borg, Felix Mitelman, Bertil Johansson, Mattias Hoglund, Thoas Fioretos;
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Hilmar Quentmeier, Roderick A.F. MacLeod, Margarete Zaborski, Hans Gunther Drexler;
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=19608861; DOI=10.1126/science.1175371
Chunaram Choudhary, Chanchal Kumar, Florian Gnad, Michael Lund Nielsen, Michael Rehman, Tobias C. Walther, Jesper Velgaard Olsen, Matthias Mann;
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science 325:834-840(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20922763; DOI=10.1002/pbc.22801; PMCID=PMC3005554
Min H. Kang, Malcolm A. Smith, Christopher L. Morton, Nino Keshelava, Peter J. Houghton, Charles Patrick Reynolds;
National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
Pediatr. Blood Cancer 56:239-249(2011)

PubMed=21552520; DOI=10.1371/journal.pone.0019169; PMCID=PMC3084268
Ting-Lei Gu, Julie Nardone, Yi Wang, Marc Loriaux, Judit Villen, Sean A. Beausoleil, Meghan Tucker, Jon M. Kornhauser, Jian-Min Ren, Joan MacNeill, Steven P. Gygi ...Show all 15 authors... , Brian Jay Druker, Michael Charles Heinrich, John Rush, Roberto D. Polakiewicz; Show fewer authors
Survey of activated FLT3 signaling in leukemia.
PLoS ONE 6:e19169.1-e19169.10(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda ...Show all 14 authors... , De-Chen Lin, Henry He Yang, Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680
Rafal Skopek, Malgorzata Palusinska, Katarzyna Kaczor-Keller, Rafal Pingwara, Anna Papierniak-Wygladala, Tino Schenk, Slawomir Lewicki, Artur Zelent, Lukasz Szymanski;
Choosing the right cell line for acute myeloid leukemia (AML) research.
Int. J. Mol. Sci. 24:5377.1-5377.34(2023)

Cross-references
Cell line collections (Providers) AddexBio; C0003025/4955
ATCC; CRL-9591
ATCC; HTB-189 - Discontinued
CLS; 300295
DSMZ; ACC-102
Ubigene; YC-C060
Cell line databases/resources CLO; CLO_0007906
CLDB; cl3610
CLDB; cl3611
cancercelllines; CVCL_0064
CCRID; 3101HUMSCSP5031
Cell_Model_Passport; SIDM00657
Cosmic-CLP; 908156
DepMap; ACH-000045
DSMZCellDive; ACC-102
IGRhCellID; MV4II
LINCS_LDP; LCL-1092
Lonza; 996
TOKU-E; 2536
Anatomy/cell type resources BTO; BTO_0006413
Biological sample resources BioSample; SAMN01821582
BioSample; SAMN01821649
BioSample; SAMN03473104
BioSample; SAMN10988366
CRISP screens repositories BioGRID_ORCS_Cell_line; 138
Chemistry resources ChEMBL-Cells; CHEMBL3308063
ChEMBL-Targets; CHEMBL613835
GDSC; 908156
PharmacoDB; MV411_972_2019
PubChem_Cell_line; CVCL_0064
Encyclopedic resources Wikidata; Q54907109
Experimental variables resources EFO; EFO_0002242
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10718-109I7
GEO; GSM236796
GEO; GSM236832
GEO; GSM482560
GEO; GSM887344
GEO; GSM888420
GEO; GSM1374694
GEO; GSM1446746
GEO; GSM1670137
Polymorphism and mutation databases Cosmic; 787416
Cosmic; 798673
Cosmic; 908156
Cosmic; 975284
Cosmic; 994182
Cosmic; 996315
Cosmic; 1012104
Cosmic; 1037736
Cosmic; 1078732
Cosmic; 1089516
Cosmic; 1127256
Cosmic; 1150899
Cosmic; 1152712
Cosmic; 1181603
Cosmic; 1278781
Cosmic; 1281340
Cosmic; 1308221
Cosmic; 1319550
Cosmic; 1451846
Cosmic; 1476424
Cosmic; 1516631
Cosmic; 1524837
Cosmic; 1623635
Cosmic; 1696137
Cosmic; 1779133
Cosmic; 2131568
Cosmic; 2306226
Cosmic; 2392908
Cosmic; 2393011
Cosmic; 2542841
Cosmic; 2750867
IARC_TP53; 21521
LiGeA; CCLE_055
Progenetix; CVCL_0064
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number49