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Cellosaurus Hep-G2-THRB (CVCL_C3GC)

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Cell line name Hep-G2-THRB
Synonyms TRbeta1-WT
Accession CVCL_C3GC
Resource Identification Initiative To cite this cell line use: Hep-G2-THRB (RRID:CVCL_C3GC)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11799; THRB.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=19749797; DOI=10.1038/onc.2009.265; PMCID=PMC2787677
Ivan H. Chan, Martin Lawrence Privalsky;
Thyroid hormone receptor mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire.
Oncogene 28:4162-4174(2009)

PubMed=21622534; DOI=10.1210/me.2010-0420; PMCID=PMC3146248
Meghan D. Rosen, Ivan H. Chan, Martin Lawrence Privalsky;
Mutant thyroid hormone receptors (TRs) isolated from distinct cancer types display distinct target gene specificities: a unique regulatory repertoire associated with two renal clear cell carcinomas.
Mol. Endocrinol. 25:1311-1325(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C3GC
Encyclopedic resources Wikidata; Q114311596
Gene expression databases GEO; GSM721660
GEO; GSM721661
GEO; GSM721662
GEO; GSM721663
GEO; GSM721664
GEO; GSM721665
Entry history
Entry creation22-Sep-2022
Last entry update14-Aug-2025
Version number9