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Cellosaurus SU-DIPG-XXXV (CVCL_C1MJ)

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Cell line name SU-DIPG-XXXV
Synonyms SU-DIPG-35; SU-DIPG 35; Stanford University-Diffuse Intrinsic Pontine Glioma-XXXV
Accession CVCL_C1MJ
Resource Identification Initiative To cite this cell line use: SU-DIPG-XXXV (RRID:CVCL_C1MJ)
Comments Derived from site: In situ; Brainstem, pons; UBERON=UBERON_0000988.
Sequence variations
  • Mutation; HGNC; HGNC:4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Unspecified (PubMed=34732238).
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Ser432Ter; Zygosity=Unspecified (PubMed=34732238).
Disease Diffuse intrinsic pontine glioma (NCIt: C94764)
Diffuse intrinsic pontine glioma (ORDO: Orphanet_497188)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Cancer cell line
STR profile Source(s): PubMed=34732238

Markers:
AmelogeninX
CSF1PO10,12
D5S81812
D7S82010,13
D13S31712,13
D16S5399,12
D21S1131.2,32.2
TH016,7
TPOX8
vWA15,16

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Publications

PubMed=31439867; DOI=10.1038/s41467-019-11732-6; PMCID=PMC6706443
Nathan R. Fons, Ranjini K. Sundaram, Gregory A. Breuer, Sen Peng, Ryan L. McLean, Aravind N. Kalathil, Mark S. Schmidt, Diana M. Carvalho, Alan Mackay, Chris Jones, Angel Montero Carcaboso ...Show all 15 authors... , Javad Nazarian, Michael E. Berens, Charles Brenner, Ranjit S. Bindra; Show fewer authors
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
Nat. Commun. 10:3790.1-3790.10(2019)

PubMed=33319914; DOI=10.1093/gigascience/giaa136; PMCID=PMC7736793
Lauren M. Sanders, Allison Cheney, Lucas Seninge, Anouk van den Bout, Marissa Chen, Holly Conley Beale, Ellen Towle Kephart, Jacob Pfeil, Katrina Learned, A. Geoffrey Lyle, Isabel Bjork ...Show all 14 authors... , David Haussler, Sofie Reda Salama, Olena M. Vaske; Show fewer authors
Identification of a differentiation stall in epithelial mesenchymal transition in histone H3-mutant diffuse midline glioma.
GigaScience 9:giaa136.1-giaa136.14(2020)

PubMed=34732238; DOI=10.1186/s40478-021-01270-y; PMCID=PMC8565061
Cheng Xu, Heng Liu, Christopher J. Pirozzi, Lee H. Chen, Paula K. Greer, Bill H. Diplas, Li-Wei Zhang, Matthew S. Waitkus, Yi-Ping He, Hai Yan;
TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist.
Acta Neuropathol. Commun. 9:178.1-178.12(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C1MJ
Encyclopedic resources Wikidata; Q114313066
Entry history
Entry creation22-Sep-2022
Last entry update27-Nov-2025
Version number7