ID   SU-DIPG-XXXV
AC   CVCL_C1MJ
SY   SU-DIPG-35; SU-DIPG 35
DR   cancercelllines; CVCL_C1MJ
DR   Wikidata; Q114313066
RX   PubMed=31439867;
RX   PubMed=33319914;
RX   PubMed=34732238;
CC   Sequence variation: Mutation; HGNC; HGNC:4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Unspecified (PubMed=34732238).
CC   Sequence variation: Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Ser432Ter; Zygosity=Unspecified (PubMed=34732238).
CC   Derived from site: In situ; Brainstem, pons; UBERON=UBERON_0000988.
ST   Source(s): PubMed=34732238
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 12,13
ST   D16S539: 9,12
ST   D21S11: 31.2,32.2
ST   D5S818: 12
ST   D7S820: 10,13
ST   TH01: 6,7
ST   TPOX: 8
ST   vWA: 15,16
DI   NCIt; C94764; Diffuse intrinsic pontine glioma
DI   ORDO; Orphanet_497188; Diffuse intrinsic pontine glioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 19-12-24; Version: 6
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RX   PubMed=31439867; DOI=10.1038/s41467-019-11732-6; PMCID=PMC6706443;
RA   Fons N.R., Sundaram R.K., Breuer G.A., Peng S., McLean R.L.,
RA   Kalathil A.N., Schmidt M.S., Carvalho D.M., Mackay A., Jones C.,
RA   Carcaboso A.M., Nazarian J., Berens M.E., Brenner C., Bindra R.S.;
RT   "PPM1D mutations silence NAPRT gene expression and confer NAMPT
RT   inhibitor sensitivity in glioma.";
RL   Nat. Commun. 10:3790.1-3790.10(2019).
//
RX   PubMed=33319914; DOI=10.1093/gigascience/giaa136; PMCID=PMC7736793;
RA   Sanders L.M., Cheney A., Seninge L., van den Bout A., Chen M.,
RA   Beale H.C., Kephart E.T., Pfeil J., Learned K., Lyle A.G., Bjork I.,
RA   Haussler D., Salama S.R., Vaske O.M.;
RT   "Identification of a differentiation stall in epithelial mesenchymal
RT   transition in histone H3-mutant diffuse midline glioma.";
RL   GigaScience 9:giaa136.1-giaa136.14(2020).
//
RX   PubMed=34732238; DOI=10.1186/s40478-021-01270-y; PMCID=PMC8565061;
RA   Xu C., Liu H., Pirozzi C.J., Chen L.H., Greer P.K., Diplas B.H.,
RA   Zhang L.-W., Waitkus M.S., He Y.-P., Yan H.;
RT   "TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are
RT   sensitive to a MDM2 antagonist.";
RL   Acta Neuropathol. Commun. 9:178.1-178.12(2021).
//