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Cellosaurus U-2OS-Cas9-4 (CVCL_C0ZD)

[Text version]
Cell line name U-2OS-Cas9-4
Accession CVCL_C0ZD
Resource Identification Initiative To cite this cell line use: U-2OS-Cas9-4 (RRID:CVCL_C0ZD)
Comments Population: Caucasian.
Characteristics: Transfected with a Cas9-T2A-PuroR construct.
Transfected with: UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; 9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line

PubMed=35445373; DOI=10.1007/s11010-022-04434-z
Zhou Y.-H., Li Y.-J., Zhang Y., Yi Z.-L., Jiang M.-G.
Establishment and application of a human osteosarcoma U-2OS cell line that can stably express Cas9 protein.
Mol. Cell. Biochem. 477:2183-2191(2022)

Encyclopedic resources Wikidata; Q114313141
Entry history
Entry creation22-Sep-2022
Last entry update05-Oct-2023
Version number5