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Cellosaurus BEL-A BSG KO (CVCL_C0XA)

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Cell line name BEL-A BSG KO
Synonyms Basigin KO BEL-A
Accession CVCL_C0XA
Resource Identification Initiative To cite this cell line use: BEL-A BSG KO (RRID:CVCL_C0XA)
Comments Group: Malaria research cell line.
Characteristics: Induced differentiated reticulocytes are completely refractory to invasion by Plasmodium falciparum (PubMed=31444345).
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:1116; BSG.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Mononuclear cell of bone marrow; CL=CL_0010004.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C0X7 (BEL-A2 clone 79)
Sex of cell Sex unspecified
Age at sampling Adult
Category Transformed cell line
Publications

CLPUB00710
Joseph Samuel Hawksworth;
CRISPR-Cas9 gene editing in an immortalized erythroid cell line for production of engineered red blood cells.
Thesis PhD (2019); University of Bristol; Bristol; United Kingdom

PubMed=31444345; DOI=10.1038/s41467-019-11790-w; PMCID=PMC6707200
Timothy J. Satchwell, Katherine E. Wright, Katy L. Haydn-Smith, Fernando Sanchez-Roman Teran, Pedro L. Moura, Joseph Samuel Hawksworth, Jan Frayne, Ashley Mark Toye, Jake Baum;
Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements.
Nat. Commun. 10:3806.1-3806.9(2019)

Cross-references
Encyclopedic resources Wikidata; Q114310731
Entry history
Entry creation22-Sep-2022
Last entry update10-Apr-2025
Version number9