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Cellosaurus BEL-A2 clone 79 (CVCL_C0X7)

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Cell line name BEL-A2 clone 79
Synonyms BEL-A2 clone #79
Accession CVCL_C0X7
Resource Identification Initiative To cite this cell line use: BEL-A2 clone 79 (RRID:CVCL_C0X7)
Comments Group: Malaria research cell line.
Characteristics: Induced differentiated reticulocytes can sustain invasion and growth of Plasmodium falciparum (PubMed=31444345).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Genomics; Whole genome sequencing.
Omics: Proteomics; Quantitative.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Mononuclear cell of bone marrow; CL=CL_0010004.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_JM04 (BEL-A)
Children:
CVCL_C0X9 (BEL-A ACKR1 KO)CVCL_C0XA (BEL-A BSG KO)CVCL_C0XB (BEL-A FUT1 KO)
CVCL_C0XC (BEL-A GPA KO)CVCL_C0XD (BEL-A GPB KO)CVCL_C0XE (BEL-A KEL KO)
CVCL_C0XF (BEL-A RHAG KO)CVCL_C0XG (BEL-A RHCE KO)
Sex of cell Sex unspecified
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=29700043; DOI=10.15252/emmm.201708454; PMCID=PMC5991592
Joseph Samuel Hawksworth, Timothy J. Satchwell, Marjolein Meinders, Deborah E. Daniels, Fiona Regan, Nicole M. Thornton, Marieangela C. Wilson, Johannes G.G. Dobbe, Geert J. Streekstra, Kongtana Trakarnsanga, Kate J. Heesom ...Show all 14 authors... , David John Anstee, Jan Frayne, Ashley Mark Toye; Show fewer authors
Enhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing.
EMBO Mol. Med. 10:e8454.1-e8454.11(2018)

CLPUB00710
Joseph Samuel Hawksworth;
CRISPR-Cas9 gene editing in an immortalized erythroid cell line for production of engineered red blood cells.
Thesis PhD (2019); University of Bristol; Bristol; United Kingdom

PubMed=31444345; DOI=10.1038/s41467-019-11790-w; PMCID=PMC6707200
Timothy J. Satchwell, Katherine E. Wright, Katy L. Haydn-Smith, Fernando Sanchez-Roman Teran, Pedro L. Moura, Joseph Samuel Hawksworth, Jan Frayne, Ashley Mark Toye, Jake Baum;
Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements.
Nat. Commun. 10:3806.1-3806.9(2019)

Cross-references
Encyclopedic resources Wikidata; Q114310732
Proteomic databases PRIDE; PXD009291
Entry history
Entry creation22-Sep-2022
Last entry update10-Apr-2025
Version number8