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Cellosaurus A375 PLX/AZD-resistant (CVCL_C0Q6)

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Cell line name A375 PLX/AZD-resistant
Accession CVCL_C0Q6
Resource Identification Initiative To cite this cell line use: A375 PLX/AZD-resistant (RRID:CVCL_C0Q6)
Comments Population: Caucasian.
Characteristics: Established by growing the parent cell line in an increasing concentration PLX4032 and AZD6244 up to a concentration of 1 microMolar (PubMed=35128241).
Selected for resistance to: ChEBI; CHEBI_63637; Vemurafenib (Zelboraf; PLX4032).
Selected for resistance to: ChEBI; CHEBI_90227; Selumetinib (AZD6244).
Omics: Proteomics; Quantitative.
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=35128241; DOI=10.1021/acsomega.1c05361; PMCID=PMC8811929
Ramon Martinez 3rd, Wei-Liang Huang, Heather Buck, Samantha Rea, Amy E. Defnet, Maureen A. Kane, Paul Shapiro;
Proteomic changes in the monolayer and spheroid melanoma cell models of acquired resistance to BRAF and MEK1/2 inhibitors.
ACS Omega 7:3293-3311(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0Q6
Encyclopedic resources Wikidata; Q112927056
Proteomic databases PRIDE; PXD026952
Entry history
Entry creation23-Jun-2022
Last entry update27-Nov-2025
Version number9