Cellosaurus logo
expasy logo

Cellosaurus 2C4 gamma2A/JAK2 (CVCL_C0D5)

[Text][XML][JSON]
Cell line name 2C4 gamma2A/JAK2
Synonyms Gamma2A Jak2; Gamma2A/JAK2
Accession CVCL_C0D5
Resource Identification Initiative To cite this cell line use: 2C4 gamma2A/JAK2 (RRID:CVCL_C0D5)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:1639; CD2.
Genetic integration: Method=Transfection; Gene=MGI; MGI:96629; Jak2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Transformant: ChEBI; CHEBI_132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C0D4 (2C4 gamma2A)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=9001223; DOI=10.1128/mcb.17.2.695; PMCID=PMC231795
Franz Kohlhuber, Neil C. Rogers, Diane Watling, Jian Feng, Dmitry Y. Guschin, James Briscoe, Bruce A. Witthuhn, Serguei V. Kotenko, Sidney Pestka, George Robert Stark, James N. Ihle, Ian Macpherson Kerr;
A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.
Mol. Cell. Biol. 17:695-706(1997)

Cross-references
Cell line collections (Providers) CancerTools; 151681
Ximbio; 151681
Cell line databases/resources cancercelllines; CVCL_C0D5
Encyclopedic resources Wikidata; Q112926938
Entry history
Entry creation23-Jun-2022
Last entry update14-Aug-2025
Version number10