Cellosaurus cell line 2C4 gamma1A (CVCL

Cellosaurus 2C4 gamma1A (CVCL_C0D3)

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Cell line name

2C4 gamma1A

Synonyms

gamma1A

Accession

CVCL_C0D3

Resource Identification Initiative

To cite this cell line use: 2C4 gamma1A (RRID:CVCL_C0D3)

Comments

Population: Caucasian.
Characteristics: Retain a normal IFN-alpha/beta response but is completely defective in the IFN-gamma response (PubMed=9001223).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:1639; CD2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: ChEBI; CHEBI_132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.

Sequence variations

Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:5440; IFNGR2; Simple; p.Thr299Aspfs*16 (c.897dupT); Zygosity=Homozygous (PubMed=9001223).
Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).

Disease

Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_1D50 (2C4 [Human fibrosarcoma])
Children:

CVCL_1D51 (2C4 gamma1A/JAK2)

Sex of cell

Male

Age at sampling

35Y