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Cellosaurus 2C4 gamma1A (CVCL_C0D3)

[Text version]
Cell line name 2C4 gamma1A
Synonyms gamma1A
Accession CVCL_C0D3
Resource Identification Initiative To cite this cell line use: 2C4 gamma1A (RRID:CVCL_C0D3)
Comments Population: Caucasian.
Characteristics: Retain a normal IFN-alpha/beta response but is completely defective in the IFN-gamma response (PubMed=9001223).
Transfected with: HGNC; 1639; CD2.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 5440; IFNGR2; Simple; p.Thr299Aspfs*16 (c.897dupT); Zygosity=Homozygous (PubMed=9001223).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D50 (2C4 [Human fibrosarcoma])
Children:
CVCL_1D51 (2C4 gamma1A/JAK2)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=7901766; DOI=10.1038/366166a0
Watling D., Guschin D.Y., Muller M., Silvennoinen O., Witthuhn B.A., Quelle F.W., Rogers N.C., Schindler C., Stark G.R., Ihle J.N., Kerr I.M.
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.
Nature 366:166-170(1993)

PubMed=9001223; DOI=10.1128/mcb.17.2.695
Kohlhuber F., Rogers N.C., Watling D., Feng J., Guschin D.Y., Briscoe J., Witthuhn B.A., Kotenko S.V., Pestka S., Stark G.R., Ihle J.N., Kerr I.M.
A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.
Mol. Cell. Biol. 17:695-706(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0D3
Encyclopedic resources Wikidata; Q112926935
Entry history
Entry creation23-Jun-2022
Last entry update05-Oct-2023
Version number6