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Cellosaurus 2C4 gamma1A/JAK2 (CVCL_1D51)

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Cell line name 2C4 gamma1A/JAK2
Synonyms Gamma1A Jak2; Gamma1A/JAK2
Accession CVCL_1D51
Resource Identification Initiative To cite this cell line use: 2C4 gamma1A/JAK2 (RRID:CVCL_1D51)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:1639; CD2.
Genetic integration: Method=Transfection; Gene=MGI; MGI:96629; Jak2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Transformant: ChEBI; CHEBI_132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5440; IFNGR2; Simple; p.Thr299Aspfs*16 (c.897dupT); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C0D3 (2C4 gamma1A)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=7901766; DOI=10.1038/366166a0
Diane Watling, Dmitry Y. Guschin, Mathias Muller, Olli Silvennoinen, Bruce A. Witthuhn, Frederick W. Quelle, Neil C. Rogers, Chris Schindler, George Robert Stark, James N. Ihle, Ian Macpherson Kerr;
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.
Nature 366:166-170(1993)

PubMed=9001223; DOI=10.1128/mcb.17.2.695; PMCID=PMC231795
Franz Kohlhuber, Neil C. Rogers, Diane Watling, Jian Feng, Dmitry Y. Guschin, James Briscoe, Bruce A. Witthuhn, Serguei V. Kotenko, Sidney Pestka, George Robert Stark, James N. Ihle, Ian Macpherson Kerr;
A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.
Mol. Cell. Biol. 17:695-706(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_1D51
Encyclopedic resources Wikidata; Q54584425
Entry history
Entry creation08-Jul-2015
Last entry update14-Aug-2025
Version number15