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Cellosaurus 2C4 gamma1A/JAK2 (CVCL_1D51)

[Text version]
Cell line name 2C4 gamma1A/JAK2
Synonyms Gamma1A Jak2; Gamma1A/JAK2
Accession CVCL_1D51
Resource Identification Initiative To cite this cell line use: 2C4 gamma1A/JAK2 (RRID:CVCL_1D51)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:1639; CD2.
Genetic integration: Method=Transfection; Gene=MGI; MGI:96629; Jak2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: ChEBI; CHEBI_132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5440; IFNGR2; Simple; p.Thr299Aspfs*16 (c.897dupT); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C0D3 (2C4 gamma1A)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=7901766; DOI=10.1038/366166a0
Watling D., Guschin D.Y., Muller M., Silvennoinen O., Witthuhn B.A., Quelle F.W., Rogers N.C., Schindler C., Stark G.R., Ihle J.N., Kerr I.M.
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.
Nature 366:166-170(1993)

PubMed=9001223; DOI=10.1128/mcb.17.2.695; PMCID=PMC231795
Kohlhuber F., Rogers N.C., Watling D., Feng J., Guschin D.Y., Briscoe J., Witthuhn B.A., Kotenko S.V., Pestka S., Stark G.R., Ihle J.N., Kerr I.M.
A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.
Mol. Cell. Biol. 17:695-706(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_1D51
Encyclopedic resources Wikidata; Q54584425
Entry history
Entry creation08-Jul-2015
Last entry update10-Apr-2025
Version number14