Cellosaurus cell line UM4-6 (CVCL

Cellosaurus UM4-6 (CVCL_B840)

Cross-references
Cell line name	UM4-6
Accession	CVCL_B840
Resource Identification Initiative	To cite this cell line use: UM4-6 (RRID:CVCL_B840)
Comments	From: University of Michigan; Ann Arbor; USA. Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-12-0147. Omics: Genomics; Whole exome sequencing. Omics: Transcriptomics; RNAseq. Omics: Variations; SNP array analysis. Donor information: Embryo is sibling to those giving rise to UM4-9 (Cellosaurus=CVCL_5H77), UM4-11 (Cellosaurus=CVCL_5H75), UM4-12 (Cellosaurus=CVCL_5H76) and UM4-13 (Cellosaurus=CVCL_WW08). Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358. Cell type: Embryonic stem cell; CL=CL_0002322.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Sex unspecified
Age at sampling	Blastocyst stage
Category	Embryonic stem cell
Web pages	Info; U-M; -; https://record.umich.edu/articles/a3647-new-stem-cell/ Provider; MStem Cell; -; https://www.mstemcell.org/purchase-stem-cell-lines/
Publications	PubMed=28445466; DOI=10.1038/nature22312; PMCID=PMC5427175 Florian T. Merkle, Sulagna Ghosh, Nolan Kamitaki, Jana Mitchell, Yishai Avior, Curtis Mello, Seva Kashin, Shila Mekhoubad, Dusko Ilic, Maura Charlton, Genevieve Saphier ...Show all 17 authors... , Robert E. Handsaker, Giulio Genovese, Shiran Bar, Nissim Benvenisty, Steven A. McCarroll, Kevin Carl Eggan; Show fewer authors Human pluripotent stem cells recurrently acquire and expand dominant negative p53 mutations. Nature 545:229-233(2017) PubMed=30158855; DOI=10.3389/fnmol.2018.00282; PMCID=PMC6104480 Jill M. Haenfler, Geena Skariah, Caitlin M. Rodriguez, Andre Monteiro da Rocha, Jack M. Parent, Gary D. Smith, Peter K. Todd; Targeted reactivation of FMR1 transcription in fragile X syndrome embryonic stem cells. Front. Mol. Neurosci. 11:282.1-282.17(2018) PubMed=31374463; DOI=10.1016/j.scr.2019.101504; PMCID=PMC6736695 Lauren Rebecca Moore, Laura Keller, David D. Bushart, Rodrigo G. Delatorre, Duo-Jia Li, Hayley S. McLoughlin, Maria do Carmo Costa, Vikram G. Shakkottai, Gary D. Smith, Henry Lauris Paulson; Antisense oligonucleotide therapy rescues aggresome formation in a novel spinocerebellar ataxia type 3 human embryonic stem cell line. Stem Cell Res. 39:101504-101504(2019)
Cell line databases/resources	NIHhESC; NIHhESC-12-0147
Encyclopedic resources	Wikidata; Q54991044
Gene expression databases	GEO; GSM3053264 GEO; GSM3053265
Entry history
Entry creation	06-Jun-2012
Last entry update	10-Apr-2025
Version number	18